Literature DB >> 10700007

Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease.

J M Bronstein1, S Tiwari-Woodruff, A G Buznikov, D B Stevens.   

Abstract

Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease. Copyright 2000 Wiley-Liss, Inc.

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Year:  2000        PMID： 10700007     DOI： 10.1002/(SICI)1097-4547(20000315)59:6<706::AID-JNR2>3.0.CO;2-D

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN： 0360-4012            Impact factor:   4.164


  25 in total

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