| Literature DB >> 10699341 |
H L Davis1, I I Suparto, R R Weeratna, D D Iskandriati, S S Chamzah, A A Ma'ruf, C C Nente, D D Pawitri, A M Krieg, W Smits, D D Sajuthi.
Abstract
Oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) have been shown to be potent Th1-type adjuvants for augmenting antigen-specific responses in mice against hepatitis B surface antigen (HBsAg). The hepatitis B virus (HBV) infects only humans and great apes and appears to exist among wild chimpanzees and orangutans. An outbreak of HBV among orangutans being rehabilitated for re-introduction to the jungle caused the death of several animals. A prophylactic vaccination program revealed that orangutans are quite hypo-responsive to a current commercial vaccine compared to results obtained previously in humans and chimpanzees. Addition of CpG ODN to hepatitis B vaccine greatly increased the seroconversion rate and the titers of antibody against HBsAg (anti-HBs). This is the first demonstration of CpG DNA in a great ape and the results have important implications for the vaccination of humans against HBV and other diseases.Entities:
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Year: 2000 PMID： 10699341 DOI： 10.1016/s0264-410x(99)00443-0
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641