Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Targeted drug delivery for brain cancer treatment.

Literature DB >> 10699267

Targeted drug delivery for brain cancer treatment.

Abstract

The blood brain barrier (BBB) and the systemic toxicity of conventional chemotherapy present obstacles to the success of future blood-borne drug therapies of brain tumors. The work with polymer-encapsulated cancer drugs suggests an alternative and more focused treatment approach. Our experimental strategy integrates direct intracerebral drug delivery, sustained drug release from liposomes or polymer implants, and increased targeting of the drug either by chemically modifying the drug or by using tumor-specific carriers. This review will present some of the recent work on targeted drug delivery for brain cancer treatment.

Entities: Disease

Mesh：

Substances：

Year: 2000 PMID： 10699267 DOI： 10.1016/s0168-3659(99)00229-1

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

Keyword Cloud
Cited

12 in total

Review 1. Planning for intracavitary anti-EGFR radionuclide therapy of gliomas. Literature review and data on EGFR expression.

Authors: J Carlsson; Z P Ren; K Wester; A L Sundberg; N E Heldin; G Hesselager; M Persson; L Gedda; V Tolmachev; H Lundqvist; E Blomquist; M Nistér
Journal: J Neurooncol Date: 2006-03 Impact factor: 4.130

2. Apoptosis-induced anticancer effect of transferrin-conjugated solid lipid nanoparticles of curcumin.

Authors: Rohit S Mulik; Jukka Mönkkönen; Risto O Juvonen; Kakasaheb R Mahadik; Anant R Paradkar
Journal: Cancer Nanotechnol Date: 2012-11-13

3. Multifunctional biodegradable polyacrylamide nanocarriers for cancer theranostics--a "see and treat" strategy.

Authors: Shouyan Wang; Gwangseong Kim; Yong-Eun Koo Lee; Hoe Jin Hah; Manivannan Ethirajan; Ravindra K Pandey; Raoul Kopelman
Journal: ACS Nano Date: 2012-07-06 Impact factor: 15.881

4. Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration.

Authors: Beata Chertok; Allan E David; Victor C Yang
Journal: Biomaterials Date: 2010-05-21 Impact factor: 12.479

Targeted drug delivery for brain cancer treatment.

Review 1. Planning for intracavitary anti-EGFR radionuclide therapy of gliomas. Literature review and data on EGFR expression.

2. Apoptosis-induced anticancer effect of transferrin-conjugated solid lipid nanoparticles of curcumin.

3. Multifunctional biodegradable polyacrylamide nanocarriers for cancer theranostics--a "see and treat" strategy.

4. Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration.

Review 5. Magnetic nanoparticles for tumor imaging and therapy: a so-called theranostic system.

6. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors.

Review 7. Adenosine-associated delivery systems.

8. Uptake of the carborane derivative of cholesteryl ester by glioma cancer cells is mediated through LDL receptors.

9. Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease.

10. Peptide-mediated targeting of liposomes to TrkB receptor-expressing cells.