OBJECTIVE: Schizophrenia is clinically heterogeneous. Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity. METHOD: Using data from the Irish Study of High-Density Schizophrenia Families (N=265 pedigrees; N=1,408 individuals), the authors attempted to predict, from major symptoms and signs of psychosis, evidence for linkage within families for schizophrenia-related disorders to chromosomal regions 5q21-5q31, 6p24-6p22, 8p22-8p21, and 10p15-10p11. RESULTS: No substantial evidence was found for associations between clinical features of schizophrenia and linkage to chromosomes 5q, 6p, or 10p. However, affected individuals from families with evidence for linkage to 8p had significantly more affective deterioration, poorer outcome, more thought disorder, and fewer depressive symptoms than affected individuals from the other families in the study. CONCLUSIONS: These results raise the possibility that the putative susceptibility gene for schizophrenia localized in the 8p22-8p21 region may predispose individuals to the core dementia-praecox syndrome described by Kraepelin more than 100 years ago.
OBJECTIVE:Schizophrenia is clinically heterogeneous. Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity. METHOD: Using data from the Irish Study of High-Density Schizophrenia Families (N=265 pedigrees; N=1,408 individuals), the authors attempted to predict, from major symptoms and signs of psychosis, evidence for linkage within families for schizophrenia-related disorders to chromosomal regions 5q21-5q31, 6p24-6p22, 8p22-8p21, and 10p15-10p11. RESULTS: No substantial evidence was found for associations between clinical features of schizophrenia and linkage to chromosomes 5q, 6p, or 10p. However, affected individuals from families with evidence for linkage to 8p had significantly more affective deterioration, poorer outcome, more thought disorder, and fewer depressive symptoms than affected individuals from the other families in the study. CONCLUSIONS: These results raise the possibility that the putative susceptibility gene for schizophrenia localized in the 8p22-8p21 region may predispose individuals to the core dementia-praecox syndrome described by Kraepelin more than 100 years ago.
Authors: Roel A Ophoff; Michael A Escamilla; Susan K Service; Mitzi Spesny; Dar B Meshi; Wingman Poon; Julio Molina; Eduardo Fournier; Alvaro Gallegos; Carol Mathews; Thomas Neylan; Steven L Batki; Erin Roche; Margarita Ramirez; Sandra Silva; Melissa C De Mille; Penny Dong; Pedro E Leon; Victor I Reus; Lodewijk A Sandkuijl; Nelson B Freimer Journal: Am J Hum Genet Date: 2002-07-15 Impact factor: 11.025
Authors: M Daniele Fallin; Virginia K Lasseter; Paula S Wolyniec; John A McGrath; Gerald Nestadt; David Valle; Kung-Yee Liang; Ann E Pulver Journal: Am J Hum Genet Date: 2003-08-15 Impact factor: 11.025
Authors: Smita N Deshpande; Triptish Bhatia; Joel Wood; Jaspreet S Brar; B K Thelma; Rohan Ganguli; Richard Day; Irving I Gottesman; Vishwajit L Nimgaonkar Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2004-05 Impact factor: 4.328
Authors: Erika Pedrosa; Radu Stefanescu; Benjamin Margolis; Oriana Petruolo; Yungtai Lo; Karen Nolan; Tomas Novak; Pavla Stopkova; Herbert M Lachman Journal: Schizophr Res Date: 2008-05-27 Impact factor: 4.939