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Literature DB >> 10698719

Imprinted genes as potential genetic and epigenetic toxicologic targets.

Abstract

Genomic imprinting is an epigenetic phenomenon in eutherian mammals that results in the differential expression of the paternally and maternally inherited alleles of a gene. Imprinted genes are necessary for normal mammalian development. This requirement has been proposed to have evolved because of an interparental genetic battle for the utilization of maternal resources during gestation and postnatally. The nonrandom requisite for monoallelic expression of a subset of genes has also resulted in the formation of susceptibility loci for neurobehavioral disorders, developmental disorders, and cancer. Since imprinting involves both cytosine methylation within CpG islands and changes in chromatin structure, imprinted genes are potential targets for dysregulation by epigenetic toxicants that modify DNA methylation and histone acetylation.

Entities: Chemical Disease Species

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Year: 2000 PMID： 10698719 PMCID： PMC1637779 DOI： 10.1289/ehp.00108s15

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

163 in total

1. Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.

Authors: F L Sun; W L Dean; G Kelsey; N D Allen; W Reik
Journal: Nature Date: 1997-10-23 Impact factor: 49.962

2. Impact of genomic imprinting on genomic instability and radiation-induced mutation.

Authors: P N Schofield
Journal: Int J Radiat Biol Date: 1998-12 Impact factor: 2.694

Review 3. DNA methylation and gene expression: introduction and overview.

Authors: C B Klein; M Costa
Journal: Mutat Res Date: 1997-04 Impact factor: 2.433

4. Allele-specific replication timing of imprinted gene regions.

Authors: D Kitsberg; S Selig; M Brandeis; I Simon; I Keshet; D J Driscoll; R D Nicholls; H Cedar
Journal: Nature Date: 1993-07-29 Impact factor: 49.962

5. Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.

Authors: T Moore; M Constancia; M Zubair; B Bailleul; R Feil; H Sasaki; W Reik
Journal: Proc Natl Acad Sci U S A Date: 1997-11-11 Impact factor: 11.205

6. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Authors: S J Darkin-Rattray; A M Gurnett; R W Myers; P M Dulski; T M Crumley; J J Allocco; C Cannova; P T Meinke; S L Colletti; M A Bednarek; S B Singh; M A Goetz; A W Dombrowski; J D Polishook; D M Schmatz
Journal: Proc Natl Acad Sci U S A Date: 1996-11-12 Impact factor: 11.205

7. Promoter-specific imprinting of the human insulin-like growth factor-II gene.

Authors: T H Vu; A R Hoffman
Journal: Nature Date: 1994-10-20 Impact factor: 49.962

8. Relaxation of imprinted genes in human cancer.

Authors: S Rainier; L A Johnson; C J Dobry; A J Ping; P E Grundy; A P Feinberg
Journal: Nature Date: 1993-04-22 Impact factor: 49.962

9. Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region.

Authors: J S Sutcliffe; M Nakao; S Christian; K H Orstavik; N Tommerup; D H Ledbetter; A L Beaudet
Journal: Nat Genet Date: 1994-09 Impact factor: 38.330

10. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

Authors: C E Rogler; D Yang; L Rossetti; J Donohoe; E Alt; C J Chang; R Rosenfeld; K Neely; R Hintz
Journal: J Biol Chem Date: 1994-05-13 Impact factor: 5.157

6 in total

Review 1. Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases.

Authors: Shuk-mei Ho; Wan-yee Tang
Journal: Reprod Toxicol Date: 2007-01-19 Impact factor: 3.143