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Literature DB >> 10698681

Alpha-synuclein overexpression promotes aggregation of mutant huntingtin.

R A Furlong¹, Y Narain, J Rankin, A Wyttenbach, D C Rubinsztein.

Abstract

Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms hyperfluorescent inclusions in PC12 cells. Inclusion formation is enhanced in cells co-transfected with EGFP-huntingtin-(CAG)(72) and alpha-synuclein, a major component of Parkinson's disease aggregates. However, alpha-synuclein does not form aggregates by itself, nor does it appear in huntingtin inclusions in vitro.

Entities: Disease Gene

Mesh：

Substances：

Year: 2000 PMID： 10698681 PMCID： PMC1220887

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

30 in total

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Authors: E Mezey; A Dehejia; G Harta; M I Papp; M H Polymeropoulos; M J Brownstein
Journal: Nat Med Date: 1998-07 Impact factor: 53.440

2. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

Authors: R Krüger; W Kuhn; T Müller; D Woitalla; M Graeber; S Kösel; H Przuntek; J T Epplen; L Schöls; O Riess
Journal: Nat Genet Date: 1998-02 Impact factor: 38.330

3. Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

Authors: S Igarashi; R Koide; T Shimohata; M Yamada; Y Hayashi; H Takano; H Date; M Oyake; T Sato; A Sato; S Egawa; T Ikeuchi; H Tanaka; R Nakano; K Tanaka; I Hozumi; T Inuzuka; H Takahashi; S Tsuji
Journal: Nat Genet Date: 1998-02 Impact factor: 38.330

4. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.

Authors: D Martindale; A Hackam; A Wieczorek; L Ellerby; C Wellington; K McCutcheon; R Singaraja; P Kazemi-Esfarjani; R Devon; S U Kim; D E Bredesen; F Tufaro; M R Hayden
Journal: Nat Genet Date: 1998-02 Impact factor: 38.330

5. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.

Authors: M DiFiglia; E Sapp; K O Chase; S W Davies; G P Bates; J P Vonsattel; N Aronin
Journal: Science Date: 1997-09-26 Impact factor: 47.728

6. A molecular investigation of true dominance in Huntington's disease.

Authors: Y Narain; A Wyttenbach; J Rankin; R A Furlong; D C Rubinsztein
Journal: J Med Genet Date: 1999-10 Impact factor: 6.318

7. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins.

Authors: J M Jenco; A Rawlingson; B Daniels; A J Morris
Journal: Biochemistry Date: 1998-04-07 Impact factor: 3.162

8. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

Authors: J K Cooper; G Schilling; M F Peters; W J Herring; A H Sharp; Z Kaminsky; J Masone; F A Khan; M Delanoy; D R Borchelt; V L Dawson; T M Dawson; C A Ross
Journal: Hum Mol Genet Date: 1998-05 Impact factor: 6.150

9. Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

Authors: M Holmberg; C Duyckaerts; A Dürr; G Cancel; I Gourfinkel-An; P Damier; B Faucheux; Y Trottier; E C Hirsch; Y Agid; A Brice
Journal: Hum Mol Genet Date: 1998-05 Impact factor: 6.150

10. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

Authors: C J Cummings; M A Mancini; B Antalffy; D B DeFranco; H T Orr; H Y Zoghbi
Journal: Nat Genet Date: 1998-06 Impact factor: 38.330

31 in total

1. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

Authors: L Stefanis; K E Larsen; H J Rideout; D Sulzer; L A Greene
Journal: J Neurosci Date: 2001-12-15 Impact factor: 6.167

2. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.

Authors: Ana Jorge-Finnigan; Rune Kleppe; Kunwar Jung-Kc; Ming Ying; Michael Marie; Ivan Rios-Mondragon; Michael F Salvatore; Jaakko Saraste; Aurora Martinez
Journal: J Biol Chem Date: 2017-06-21 Impact factor: 5.157

3. Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models.

Authors: Atossa Shaltouki; Chung-Han Hsieh; Min Joo Kim; Xinnan Wang
Journal: Acta Neuropathol Date: 2018-06-09 Impact factor: 17.088

4. α-Synuclein forms non-selective cation channels and stimulates ATP-sensitive potassium channels in hippocampal neurons.

Authors: Sergej L Mironov
Journal: J Physiol Date: 2014-11-13 Impact factor: 5.182

5. Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease.

Authors: J Carmichael; J Chatellier; A Woolfson; C Milstein; A R Fersht; D C Rubinsztein
Journal: Proc Natl Acad Sci U S A Date: 2000-08-15 Impact factor: 11.205

6. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.

Authors: Dilshan S Harischandra; Dharmin Rokad; Matthew L Neal; Shivani Ghaisas; Sireesha Manne; Souvarish Sarkar; Nikhil Panicker; Gary Zenitsky; Huajun Jin; Mechelle Lewis; Xuemei Huang; Vellareddy Anantharam; Arthi Kanthasamy; Anumantha G Kanthasamy
Journal: Sci Signal Date: 2019-03-12 Impact factor: 8.192

7. Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.

Authors: Jordan Follett; Andrea Bugarcic; Zhe Yang; Nicholas Ariotti; Suzanne J Norwood; Brett M Collins; Robert G Parton; Rohan D Teasdale
Journal: J Biol Chem Date: 2016-07-06 Impact factor: 5.157