Literature DB >> 10698450

Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.

M Högberg1, P Engelhardt, L Vrang, H Zhang.   

Abstract

Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenethyl group with benzoylethyl group (compounds 11-20) have been studied. Synthesis and antiviral activities are described.

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Year:  2000        PMID： 10698450     DOI： 10.1016/s0960-894x(99)00675-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  High pressure liquid chromatographic analysis of in vivo metabolites of N-(substituted phenyl)-N'-(1,3,5-trimethyl pyrazole-4-yl)thioureas in rats.

Authors:  Bedia Kocyigit-Kaymakcioglu; Ufuk Yilmaz; Feyza Aricioglu
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Oct-Dec       Impact factor: 2.441

2.  Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity.

Authors:  Alex G Dalecki; Aruni P Malalasekera; Kaitlyn Schaaf; Olaf Kutsch; Stefan H Bossmann; Frank Wolschendorf
Journal:  Metallomics       Date:  2016-03-03       Impact factor: 4.526

3.  Synergistic catalysis: cis-cyclopropanation of benzoxazoles.

Authors:  Marta Meazza; Mark E Light; Andrea Mazzanti; Ramon Rios
Journal:  Chem Sci       Date:  2015-10-30       Impact factor: 9.825
  3 in total

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