Literature DB >> 10698442

Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids.

E J Parker1, C González Bello, J R Coggins, A R Hawkins, C Abell.   

Abstract

(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.

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Year:  2000        PMID： 10698442     DOI： 10.1016/s0960-894x(99)00660-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding.

Authors:  Samuel H Light; George Minasov; Ludmilla Shuvalova; Scott N Peterson; Michael Caffrey; Wayne F Anderson; Arnon Lavie
Journal:  Biochemistry       Date:  2011-02-21       Impact factor: 3.162

2.  Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.

Authors:  Samuel H Light; George Minasov; Ludmilla Shuvalova; Mark-Eugene Duban; Michael Caffrey; Wayne F Anderson; Arnon Lavie
Journal:  J Biol Chem       Date:  2010-11-18       Impact factor: 5.157

3.  Reassessing the type I dehydroquinate dehydratase catalytic triad: kinetic and structural studies of Glu86 mutants.

Authors:  Samuel H Light; Wayne F Anderson; Arnon Lavie
Journal:  Protein Sci       Date:  2013-02-11       Impact factor: 6.725

4.  Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation.

Authors:  Samuel H Light; Aleksandar Antanasijevic; Sankar N Krishna; Michael Caffrey; Wayne F Anderson; Arnon Lavie
Journal:  Biochemistry       Date:  2014-01-31       Impact factor: 3.162
  4 in total

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