Literature DB >> 10698435

Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.

Y Hayashi1, K Iijima, J Katada, Y Kiso.   

Abstract

Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH2Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G.

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Year:  2000        PMID： 10698435     DOI： 10.1016/s0960-894x(99)00659-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Control of cardiomyocyte gene expression as drug target.

Authors:  H Rupp; M Benkel; B Maisch
Journal:  Mol Cell Biochem       Date:  2000-09       Impact factor: 3.396

Review 2.  Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018).

Authors:  Sarfaraz Ahmad; Carlos M Ferrario
Journal:  Expert Opin Ther Pat       Date:  2018-10-10       Impact factor: 6.674

3.  3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors.

Authors:  Mahreen Arooj; Sundarapandian Thangapandian; Shalini John; Swan Hwang; Jong Keun Park; Keun Woo Lee
Journal:  Int J Mol Sci       Date:  2011-12-12       Impact factor: 5.923

4.  Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design.

Authors:  Mahreen Arooj; Songmi Kim; Sugunadevi Sakkiah; Guang Ping Cao; Yuno Lee; Keun Woo Lee
Journal:  PLoS One       Date:  2013-04-25       Impact factor: 3.240
  4 in total

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