BACKGROUND: Clinical studies have shown discrepancies in the distribution of thallium-201 and iodine 123-beta-methyl-iodophenylpentadecanoic acid (BMIPP) in patients with hypertrophic cardiomyopathy (HCM). Myocardial uptake of fluorine 18 deoxyglucose (FDG) is increased in the hypertrophic area in HCM. METHODS AND RESULTS: We examined whether the distribution of a Tl-201/BMIPP subtraction polar map correlates with that of an FDG polar map. We normalized to maximum count each Tl-201 and BMIPP bull's-eye polar map of 6 volunteers and obtained a standard Tl-201/BMIPP subtraction polar map by subtracting a normalized BMIPP bull's-eye polar map from a normalized Tl-201 bull's-eye polar map. The Tl-201/BMIPP subtraction polar map was then applied to 8 patients with HCM (mean age 65+/-12 years) to evaluate the discrepancy between Tl-201 and BMIPP distribution. We compared the Tl-201/BMIPP subtraction polar map with an FDG polar map. In patients with HCM, the Tl-201/BMIPP subtraction polar map showed a focal uptake pattern in the hypertrophic area similar to that of the FDG polar map. By quantitative analysis, the severity score of the Tl-201/BMIPP subtraction polar map was significantly correlated with the percent dose uptake of the FDG polar map. CONCLUSION: These results suggest that this new quantitative method may be an alternative to FDG positron emission tomography for the routine evaluation of HCM.
BACKGROUND: Clinical studies have shown discrepancies in the distribution of thallium-201 and iodine 123-beta-methyl-iodophenylpentadecanoic acid (BMIPP) in patients with hypertrophic cardiomyopathy (HCM). Myocardial uptake of fluorine 18 deoxyglucose (FDG) is increased in the hypertrophic area in HCM. METHODS AND RESULTS: We examined whether the distribution of a Tl-201/BMIPP subtraction polar map correlates with that of an FDG polar map. We normalized to maximum count each Tl-201 and BMIPP bull's-eye polar map of 6 volunteers and obtained a standard Tl-201/BMIPP subtraction polar map by subtracting a normalized BMIPP bull's-eye polar map from a normalized Tl-201 bull's-eye polar map. The Tl-201/BMIPP subtraction polar map was then applied to 8 patients with HCM (mean age 65+/-12 years) to evaluate the discrepancy between Tl-201 and BMIPP distribution. We compared the Tl-201/BMIPP subtraction polar map with an FDG polar map. In patients with HCM, the Tl-201/BMIPP subtraction polar map showed a focal uptake pattern in the hypertrophic area similar to that of the FDG polar map. By quantitative analysis, the severity score of the Tl-201/BMIPP subtraction polar map was significantly correlated with the percent dose uptake of the FDG polar map. CONCLUSION: These results suggest that this new quantitative method may be an alternative to FDG positron emission tomography for the routine evaluation of HCM.
Authors: M Kawamoto; N Tamaki; Y Yonekura; E Tadamura; Y Fujibayashi; Y Magata; R Nohara; S Sasayama; K Ikekubo; H Kato Journal: Ann Nucl Med Date: 1994-02 Impact factor: 2.668
Authors: C Kurata; K Tawarahara; T Taguchi; S Aoshima; A Kobayashi; N Yamazaki; H Kawai; M Kaneko Journal: J Nucl Med Date: 1992-01 Impact factor: 10.057
Authors: N Tamaki; E Tadamura; T Kudoh; N Hattori; Y Yonekura; R Nohara; S Sasayama; K Ikekubo; H Kato; J Konishi Journal: Eur J Nucl Med Date: 1996-03
Authors: P T O'Gara; R O Bonow; B J Maron; B A Damske; A Van Lingen; S L Bacharach; S M Larson; S E Epstein Journal: Circulation Date: 1987-12 Impact factor: 29.690
Authors: P Camici; L I Araujo; T Spinks; A A Lammertsma; J C Kaski; M J Shea; A P Selwyn; T Jones; A Maseri Journal: Circulation Date: 1986-07 Impact factor: 29.690