Literature DB >> 10698123

Is adrenomedullin a causal agent in some cases of type 2 diabetes?

A Martínez1, T H Elsasser, S J Bhathena, R Pío, T A Buchanan, C J Macri, F Cuttitta.   

Abstract

The study of two populations with a recent onset of type 2 diabetes showed that a subset of the patients had higher levels of adrenomedullin (AM) than the rest of the diabetics. In this subset, physiological elevations of AM might have triggered the disease in predisposed individuals. Diabetics showed higher levels of AM than healthy controls. In addition, glycemia was measured in diabetic rats after injection of saline, AM, or antiAM antibody. AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals.

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Year:  1999        PMID： 10698123     DOI： 10.1016/s0196-9781(99)00158-8

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  17 in total

Review 1.  Adrenomedullin and pregnancy: perspectives from animal models to humans.

Authors:  Patricia M Lenhart; Kathleen M Caron
Journal:  Trends Endocrinol Metab       Date:  2012-03-16       Impact factor: 12.015

2.  Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies.

Authors:  Yuanlin Dong; Ancizar Betancourt; Michael Belfort; Chandrasekhar Yallampalli
Journal:  J Clin Endocrinol Metab       Date:  2017-09-01       Impact factor: 5.958

3.  Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet.

Authors:  Yuanlin Dong; Nicola van der Walt; Kathleen A Pennington; Chandra Yallampalli
Journal:  Endocrine       Date:  2019-04-25       Impact factor: 3.633

4.  Adrenomedullin: possible predictor of insulin resistance in women with polycystic ovary syndrome.

Authors:  I Sahin; O Celik; N Celik; L Keskin; A Dogru; I Dogru; M Yürekli; S Yologlu
Journal:  J Endocrinol Invest       Date:  2011-07-25       Impact factor: 4.256

Review 5.  Adrenomedullin and diabetes.

Authors:  Hoi Kin Wong; Fai Tang; Tsang Tommy Cheung; Bernard Man Yung Cheung
Journal:  World J Diabetes       Date:  2014-06-15

6.  Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy.

Authors:  Jan J Blom; Thomas J Giove; Tara L Favazza; James D Akula; William D Eldred
Journal:  J Ocul Biol Dis Infor       Date:  2012-01-12

7.  Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice.

Authors:  Gaurav Aggarwal; Vijaya Ramachandran; Naureen Javeed; Thiruvengadam Arumugam; Shamit Dutta; George G Klee; Eric W Klee; Thomas C Smyrk; William Bamlet; Jing Jing Han; Natalia B Rumie Vittar; Mariza de Andrade; Debabrata Mukhopadhyay; Gloria M Petersen; Martin E Fernandez-Zapico; Craig D Logsdon; Suresh T Chari
Journal:  Gastroenterology       Date:  2012-09-06       Impact factor: 22.682

Review 8.  Adrenomedullin and tumour microenvironment.

Authors:  Ignacio M Larráyoz; Sonia Martínez-Herrero; Josune García-Sanmartín; Laura Ochoa-Callejero; Alfredo Martínez
Journal:  J Transl Med       Date:  2014-12-05       Impact factor: 5.531

9.  Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.

Authors:  Natalie O Karpinich; Samantha L Hoopes; Daniel O Kechele; Patricia M Lenhart; Kathleen M Caron
Journal:  Curr Hypertens Rev       Date:  2011-12

10.  Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients.

Authors:  Marta Serrano-Ponz; Carmen Rodrigo-Gasqué; Eva Siles; Esther Martínez-Lara; Laura Ochoa-Callejero; Alfredo Martínez
Journal:  Mol Med Rep       Date:  2016-03-18       Impact factor: 2.952
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