| Literature DB >> 10695670 |
A Dombrowski1, R Jenkins, S Raghoobar, G Bills, J Polishook, F Peláez, B Burgess, A Zhao, L Huang, Y Zhang, M Goetz.
Abstract
During the course of our screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors of MEK kinase. Comparative and empirical studies of fermentation conditions improved the titers of the compounds of interest. Striking changes in the ratios and amounts of the major and minor compounds in some cases were achieved by manipulations of media composition.Entities:
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Year: 1999 PMID： 10695670 DOI： 10.7164/antibiotics.52.1077
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649