Literature DB >> 10694935

The adenomatous polyposis coli protein.

I S Näthke1.   

Abstract

Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.

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Year:  1999        PMID： 10694935      PMCID： PMC395695          DOI： 10.1136/mp.52.4.169

Source DB:  PubMed          Journal:  Mol Pathol        ISSN： 1366-8714


  61 in total

Review 1.  Cellular mechanisms of wingless/Wnt signal transduction.

Authors:  H Dierick; A Bejsovec
Journal:  Curr Top Dev Biol       Date:  1999       Impact factor: 4.897

2.  Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability.

Authors:  H Yamamoto; S Kishida; M Kishida; S Ikeda; S Takada; A Kikuchi
Journal:  J Biol Chem       Date:  1999-04-16       Impact factor: 5.157

3.  Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.

Authors:  T Nakamura; F Hamada; T Ishidate; K Anai; K Kawahara; K Toyoshima; T Akiyama
Journal:  Genes Cells       Date:  1998-06       Impact factor: 1.891

4.  The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.

Authors:  L Berrueta; S K Kraeft; J S Tirnauer; S C Schuyler; L B Chen; D E Hill; D Pellman; B E Bierer
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

5.  APC mutations occur early during colorectal tumorigenesis.

Authors:  S M Powell; N Zilz; Y Beazer-Barclay; T M Bryan; S R Hamilton; S N Thibodeau; B Vogelstein; K W Kinzler
Journal:  Nature       Date:  1992-09-17       Impact factor: 49.962

6.  Identification and characterization of the familial adenomatous polyposis coli gene.

Authors:  J Groden; A Thliveris; W Samowitz; M Carlson; L Gelbert; H Albertsen; G Joslyn; J Stevens; L Spirio; M Robertson
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

7.  beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

Authors:  Y Marikawa; R P Elinson
Journal:  Mech Dev       Date:  1998-09       Impact factor: 1.882

Review 8.  Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer.

Authors:  A Ben-Ze'ev; B Geiger
Journal:  Curr Opin Cell Biol       Date:  1998-10       Impact factor: 8.382

9.  The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

Authors:  A R Moser; W F Dove; K A Roth; J I Gordon
Journal:  J Cell Biol       Date:  1992-03       Impact factor: 10.539

10.  Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

Authors:  S H Kim; K A Roth; A R Moser; J I Gordon
Journal:  J Cell Biol       Date:  1993-11       Impact factor: 10.539
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  4 in total

1.  Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome.

Authors:  J M Askham; K T Vaughan; H V Goodson; E E Morrison
Journal:  Mol Biol Cell       Date:  2002-10       Impact factor: 4.138

2.  Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy.

Authors:  A Ramburan; F Oladiran; C Smith; G P Hadley; D Govender
Journal:  J Clin Pathol       Date:  2005-01       Impact factor: 3.411

Review 3.  EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability.

Authors:  J S Tirnauer; B E Bierer
Journal:  J Cell Biol       Date:  2000-05-15       Impact factor: 10.539

4.  Prostate cancer epigenetics: a review on gene regulation.

Authors:  Lena Diaw; Karen Woodson; John W Gillespie
Journal:  Gene Regul Syst Bio       Date:  2007-12-11
  4 in total

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