OBJECTIVE: We sought to study midpregnancy placental volume in rural Indian women, its maternal determinants, and its relationship to neonatal size. STUDY DESIGN: We performed a prospective community-based study of maternal nutrition and fetal growth in 6 villages near the city of Pune. Measurements included midpregnancy placental volume determined by means of ultrasonography at 15 to 18 weeks' gestation, maternal anthropometric measurements before and during pregnancy, and maternal blood pressure and biochemical parameters during pregnancy. Neonatal size and placental weight were measured at birth. RESULTS: The mothers were short and underweight (mean height, 1.52 m; weight, 42 kg; body mass index, 18 kg/m(2)) and produced small babies (mean birth weight, 2648 g). Midpregnancy placental volume (median, 144 mL) was related to the mother's prepregnancy weight (r = 0.15; P <.001) but not to weight gain during pregnancy, blood pressure, or circulating hemoglobin, ferritin, red blood cell folate, or glucose concentrations. Midpregnancy placental volume was related to placental weight at birth (r = 0.29; P <.001) and birth weight (r = 0.25; P <.001) independent of maternal size. CONCLUSION: In Indian mothers midpregnancy placental volume is significantly associated with prepregnant maternal weight and is an independent predictor of birth weight. Our findings may provide clues to the high prevalence of low-birth-weight infants in India.
OBJECTIVE: We sought to study midpregnancy placental volume in rural Indian women, its maternal determinants, and its relationship to neonatal size. STUDY DESIGN: We performed a prospective community-based study of maternal nutrition and fetal growth in 6 villages near the city of Pune. Measurements included midpregnancy placental volume determined by means of ultrasonography at 15 to 18 weeks' gestation, maternal anthropometric measurements before and during pregnancy, and maternal blood pressure and biochemical parameters during pregnancy. Neonatal size and placental weight were measured at birth. RESULTS: The mothers were short and underweight (mean height, 1.52 m; weight, 42 kg; body mass index, 18 kg/m(2)) and produced small babies (mean birth weight, 2648 g). Midpregnancy placental volume (median, 144 mL) was related to the mother's prepregnancy weight (r = 0.15; P <.001) but not to weight gain during pregnancy, blood pressure, or circulating hemoglobin, ferritin, red blood cell folate, or glucose concentrations. Midpregnancy placental volume was related to placental weight at birth (r = 0.29; P <.001) and birth weight (r = 0.25; P <.001) independent of maternal size. CONCLUSION: In Indian mothers midpregnancy placental volume is significantly associated with prepregnant maternal weight and is an independent predictor of birth weight. Our findings may provide clues to the high prevalence of low-birth-weight infants in India.
Authors: Zulfiqar A Bhutta; Indu Gupta; Harendra de'Silva; Dharma Manandhar; Shally Awasthi; S M Moazzem Hossain; M A Salam Journal: BMJ Date: 2004-04-03
Authors: Alison D Gernand; Parul Christian; Rina Rani Paul; Saijuddin Shaikh; Alain B Labrique; Kerry J Schulze; Abu Ahmed Shamim; Keith P West Journal: J Nutr Date: 2012-09-18 Impact factor: 4.798
Authors: C R Holroyd; N C Harvey; S R Crozier; N R Winder; P A Mahon; G Ntami; K M Godfrey; H M Inskip; C Cooper Journal: Placenta Date: 2012-05-27 Impact factor: 3.481
Authors: S D'Angelo; C S Yajnik; K Kumaran; C Joglekar; H Lubree; S R Crozier; K M Godfrey; S M Robinson; C H D Fall; H M Inskip Journal: J Epidemiol Community Health Date: 2015-07-16 Impact factor: 3.710
Authors: G R Chandak; C S Janipalli; S Bhaskar; S R Kulkarni; P Mohankrishna; A T Hattersley; T M Frayling; C S Yajnik Journal: Diabetologia Date: 2006-11-09 Impact factor: 10.122
Authors: S J Woolford; E M Curtis; S D'Angelo; P Mahon; L Cooke; J K Cleal; S R Crozier; K M Godfrey; H M Inskip; C Cooper; N C Harvey Journal: Placenta Date: 2020-07-22 Impact factor: 3.481