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Literature DB >> 1069305

Heat mutagenesis in bacteriophage T4: the transversion pathway.

P M Bingham, R H Baltz, L S Ripley, J W Drake.

Abstract

Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.

Entities: Chemical Species

Mesh：

Substances：
Guanine Nucleotides

Year: 1976 PMID： 1069305 PMCID： PMC431367 DOI： 10.1073/pnas.73.11.4159

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. NEO-GUANYLIC ACID PRODUCED BY THE ACTION OF ACID ON RIBONUCLEIC ACID.

Authors: W F HEMMENS
Journal: Biochim Biophys Acta Date: 1964-10-16

2. Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger-RNA.

Authors: S P CHAMPE; S BENZER
Journal: Proc Natl Acad Sci U S A Date: 1962-04-15 Impact factor: 11.205

3. Studies on depurination of DNA by heat.

Authors: S GREER; S ZAMENHOF
Journal: J Mol Biol Date: 1962-03 Impact factor: 5.469

4. On the molecular explanation of spontaneous and induced mutations.

Authors: E FREESE
Journal: Brookhaven Symp Biol Date: 1959-11

5. EFFECTS OF HEATING DRY BACTERIA AND SPORES ON THEIR PHENOTYPE AND GENOTYPE.

Authors: S Zamenhof
Journal: Proc Natl Acad Sci U S A Date: 1960-01 Impact factor: 11.205

6. Mutagenesis of bacteriophage T4 by acridines.

Authors: A ORGEL; S BRENNER
Journal: J Mol Biol Date: 1961-12 Impact factor: 5.469

7. Properties of r mutants of bacteriophage T4 photodynamically induced in the presence of thiopyronin and psoralen.

Authors: J W Drake; J McGuire
Journal: J Virol Date: 1967-04 Impact factor: 5.103

8. Kinetics and mechanism of the acid-catalyzed hydrolysis of some purine nucleosides.

Authors: J A Zoltewicz; D F Clark; T W Sharpless; G Grahe
Journal: J Am Chem Soc Date: 1970-03-25 Impact factor: 15.419

9. Spontaneous mutations accumulating in bacteriophage T4 in the complete absence of DNA replication.

Authors: J W Drake
Journal: Proc Natl Acad Sci U S A Date: 1966-04 Impact factor: 11.205

10. Transversion mutagenesis in bacteriophage T4.

Authors: L S Ripley
Journal: Mol Gen Genet Date: 1975-11-03

9 in total

Review 1. [Polymerase chain reaction: an overview].

Authors: U Linz; H Degenhardt
Journal: Naturwissenschaften Date: 1990-11

2. Mutator mutations in bacteriophage T4 gene 42 (dHMC hydroxymethylase).

Authors: W E Williams; J W Drake
Journal: Genetics Date: 1977-07 Impact factor: 4.562

3. Heat mutagenesis in bacteriophage T4: another walk down the transversion pathway.

Authors: M C Kricker; J W Drake
Journal: J Bacteriol Date: 1990-06 Impact factor: 3.490

4. Intragenic suppression of the temperature-sensitivity caused by a mutation in a gene controlling transcription (fit) in Escherichia coli.

Authors: S B Dass; R Jayaraman
Journal: Mol Gen Genet Date: 1985