BACKGROUND: The role, if any, of parasitosis in the development of asthma remains incompletely understood; both 'protective' and 'predictive' associations have been reported. We report a study which examined immunoglobulin (Ig) E responses to two common helminths in asthmatics living in Ethiopia. OBJECTIVE: To compare the frequencies of specific IgE antibodies to Ascaris and Necator species and to Der p 1 among 84 adult asthmatics and a referent group of nonasthmatics. METHODS: A case-control analysis. RESULTS: Total IgE levels were not different between the two groups. The presence of specific IgE to Der p 1 was strongly associated with asthma (P = 0.001). Raised levels of Ascaris-(P = 0.010) and Necator- (P = 0.001) specific IgE antibodies were more common among referents; there were no associations between specific IgE production to Der p 1 and either of the two parasites. CONCLUSION: These findings confirm the association between Der p 1 sensitization and asthma among urban, adult Ethiopians. While they also indicate a negative relationship with two indicators of helminth infestation it appears that this is not mediated through the immunological response to common aeroallergens.
BACKGROUND: The role, if any, of parasitosis in the development of asthma remains incompletely understood; both 'protective' and 'predictive' associations have been reported. We report a study which examined immunoglobulin (Ig) E responses to two common helminths in asthmatics living in Ethiopia. OBJECTIVE: To compare the frequencies of specific IgE antibodies to Ascaris and Necator species and to Der p 1 among 84 adult asthmatics and a referent group of nonasthmatics. METHODS: A case-control analysis. RESULTS: Total IgE levels were not different between the two groups. The presence of specific IgE to Der p 1 was strongly associated with asthma (P = 0.001). Raised levels of Ascaris-(P = 0.010) and Necator- (P = 0.001) specific IgE antibodies were more common among referents; there were no associations between specific IgE production to Der p 1 and either of the two parasites. CONCLUSION: These findings confirm the association between Der p 1 sensitization and asthma among urban, adult Ethiopians. While they also indicate a negative relationship with two indicators of helminth infestation it appears that this is not mediated through the immunological response to common aeroallergens.
Authors: Firdaus Hamid; Aprilianto E Wiria; Linda J Wammes; Maria Mm Kaisar; Bertrand Lell; Iwan Ariawan; Hae Won Uh; Heri Wibowo; Yenny Djuardi; Sitti Wahyuni; Robert Schot; Jaco J Verweij; Ronald van Ree; Linda May; Erliyani Sartono; Maria Yazdanbakhsh; Taniawati Supali Journal: BMC Infect Dis Date: 2011-04-01 Impact factor: 3.090
Authors: Mark S Wilson; Matthew D Taylor; Adam Balic; Constance A M Finney; Jonathan R Lamb; Rick M Maizels Journal: J Exp Med Date: 2005-11-07 Impact factor: 14.307
Authors: Philip J Cooper; Neal Alexander; Ana-Lucia Moncayo; Susana M Benitez; Martha E Chico; Maritza G Vaca; George E Griffin Journal: BMC Immunol Date: 2008-06-27 Impact factor: 3.615