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Literature DB >> 10691710

New isomalabaricane triterpenes from the marine sponge Stelletta globostellata that induce morphological changes in rat fibroblasts.

N Oku¹, S Matsunaga, S i Wada, S Watabe, N Fusetani.

Abstract

Three new isomalabaricane triterpenes, 29-hydroxystelliferin D (2), 3-epi-29-hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with 0.2 microM of 2-4 exhibited unusual morphological characteristics, followed by death in 5 days.

Entities: Chemical Disease Species

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Year: 2000 PMID： 10691710 DOI： 10.1021/np990333d

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

8 in total

Review 1. Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action.

Authors: Alejandro M S Mayer; Mark T Hamann
Journal: Mar Biotechnol (NY) Date: 2003-11-03 Impact factor: 3.619

2. Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.

Authors: Jason A Clement; Mei Li; Sidney M Hecht; David G I Kingston
Journal: J Nat Prod Date: 2006-03 Impact factor: 4.050

Review 3. Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.

Authors: Sherif S Ebada; Wenhan Lin; Peter Proksch
Journal: Mar Drugs Date: 2010-02-23 Impact factor: 5.118

Review 4. Malabaricane and Isomalabaricane Triterpenoids, Including Their Glycoconjugated Forms.

Authors: Valentin A Stonik; Sophia A Kolesnikova
Journal: Mar Drugs Date: 2021-06-05 Impact factor: 5.118

5. A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp.

Authors: Simon P B Ovenden; Jonathan L Nielson; Catherine H Liptrot; Richard H Willis; Dianne M Tapiolas; Anthony D Wright; Cherie A Motti
Journal: Mar Drugs Date: 2011-11-22 Impact factor: 6.085

New isomalabaricane triterpenes from the marine sponge Stelletta globostellata that induce morphological changes in rat fibroblasts.

Review 1. Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action.

2. Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA.

Review 3. Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.

Review 4. Malabaricane and Isomalabaricane Triterpenoids, Including Their Glycoconjugated Forms.

5. A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp.

Review 6. Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges.

7. Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum.

8. Good Practices in Sponge Natural Product Studies: Revising Vouchers with Isomalabaricane Triterpenes.