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Literature DB >> 10690996

Stable weight during lamotrigine therapy: a review of 32 studies.

O Devinsky¹, A Vuong, A Hammer, P S Barrett.

Abstract

A side effect associated with the use of some antiepileptic drugs (AEDs) is change in body weight. To evaluate the effect of lamotrigine on body weight in adult patients with epilepsy, we conducted a retrospective review of data from 463 patients treated with lamotrigine in 32 clinical trials. Mean daily dose was 259 (+/-155) mg and duration of therapy was 318 (+/-87) days. The mean change in body weight was 0.5 (+/-5) kg. Lamotrigine was associated with stable body weight in patients with epilepsy.

Entities: Chemical Disease Species

Mesh：

Substances：
Triazines
Lamotrigine

Year: 2000 PMID： 10690996 DOI： 10.1212/wnl.54.4.973

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

Keyword Cloud
Cited

13 in total

Review 1. New antiepileptic drugs.

Authors: C W Bazil
Journal: Curr Neurol Neurosci Rep Date: 2001-07 Impact factor: 5.081

Review 2. [Lamotrigine in women with epilepsy. Review of present data].

Authors: B Schmitz
Journal: Nervenarzt Date: 2003-10 Impact factor: 1.214

Review 3. Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy.

Authors: Jouko I T Isojärvi; Erik Taubøll; Andrew G Herzog
Journal: CNS Drugs Date: 2005 Impact factor: 5.749

4. Effectiveness and weight effects of open-label lamotrigine with and without concomitant psychotropic medications in patients with bipolar I disorder.

Authors: Michael N Zarzar; Jay Graham; Jeremy Roberts; Thomas Thompson; Kevin Nanry
Journal: MedGenMed Date: 2007-05-22

Review 5. Safety and tolerability of lamotrigine for bipolar disorder.

Authors: Charles L Bowden; Gregory M Asnis; Lawrence D Ginsberg; Beth Bentley; Robert Leadbetter; Robin White
Journal: Drug Saf Date: 2004 Impact factor: 5.606

Review 6. Effect of antiepileptic drugs on bodyweight: overview and clinical implications for the treatment of epilepsy.

Authors: Victor Biton
Journal: CNS Drugs Date: 2003 Impact factor: 5.749

7. Deprescribing in a Youth with an Intellectual Disability, Autism, Behavioural Problems, and Medication-Related Obesity: A Case Study.

Authors: John D McLennan
Journal: J Can Acad Child Adolesc Psychiatry Date: 2019-11-01