Nonsteroidal anti-inflammatory drug use in dentistry: gastrointestinal implications.

Pain management long has been an important consideration in dental care. Nonopioid analgesics such as aspirin, acetaminophen, and many of the nonsteroidal anti-inflammatory drugs (NSAIDs) generally provide predictable outcomes for control of dental pain because of their analgesic and anti-inflammatory properties. The anti-inflammatory action of NSAIDs also is being investigated in treatment of periodontal disease when used as an adjunct to non-surgical management. Since NSAID use by dental patients is high, gastrointestinal complications may arise, affecting long-term use of these agents. Systemic considerations of NSAID use are reviewed, as are complications frequently resulting in ulceration of the gastric mucosa.