Literature DB >> 10686386

Differential expression patterns of the basic helix-loop-helix transcription factors during aging of the murine brain.

M Uittenbogaard1, A Chiaramello.   

Abstract

In this study, we investigated the expression pattern of the basic Helix-Loop-Helix transcription factors during brain aging. We provide the first evidence that NeuroD and ME2 are differentially expressed during brain aging. Modulation of their expression is specific to distinct areas of the aging brain. NeuroD expression is sustained at high levels in aging cerebellum, whereas it severely declines in aging hippocampus. In contrast, the bHLH E-protein ME2 remains expressed in both aged cerebellum and hippocampus, although at lower levels. These observations support the idea that a shift in the transcriptional dynamics controlling gene expression is associated with the progressive functional decline observed during brain aging.

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Year:  2000        PMID： 10686386     DOI： 10.1016/s0304-3940(00)00761-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

Review 1.  Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective.

Authors:  Boris B Quednow; Magdalena M Brzózka; Moritz J Rossner
Journal:  Cell Mol Life Sci       Date:  2014-01-12       Impact factor: 9.261

2.  Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating.

Authors:  Boris B Quednow; Jürgen Brinkmeyer; Arian Mobascher; Michael Nothnagel; Francesco Musso; Gerhard Gründer; Noah Savary; Nadine Petrovsky; Ingo Frommann; Leonhard Lennertz; Katja N Spreckelmeyer; Thomas F Wienker; Norbert Dahmen; Norbert Thuerauf; Marion Clepce; Falk Kiefer; Tomislav Majic; Rainald Mössner; Wolfgang Maier; Jürgen Gallinat; Amalia Diaz-Lacava; Mohammad R Toliat; Holger Thiele; Peter Nürnberg; Michael Wagner; Georg Winterer
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

Review 3.  The role of BETA2/NeuroD1 in the development of the nervous system.

Authors:  Jang-Hyeon Cho; Ming-Jer Tsai
Journal:  Mol Neurobiol       Date:  2004-08       Impact factor: 5.590

4.  NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction.

Authors:  Hui Zheng; Yue Zhang; Wen Li; Horace H Loh; Ping-Yee Law
Journal:  Neuropsychopharmacology       Date:  2012-11-29       Impact factor: 7.853

5.  The neurogenic factor NeuroD1 is expressed in post-mitotic cells during juvenile and adult Xenopus neurogenesis and not in progenitor or radial glial cells.

Authors:  Laure Anne D'Amico; Daniel Boujard; Pascal Coumailleau
Journal:  PLoS One       Date:  2013-06-14       Impact factor: 3.240

6.  Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.

Authors:  Mari Sepp; Kaja Kannike; Ave Eesmaa; Mari Urb; Tõnis Timmusk
Journal:  PLoS One       Date:  2011-07-15       Impact factor: 3.240

7.  Differential Roles of Environmental Enrichment in Alzheimer's Type of Neurodegeneration and Physiological Aging.

Authors:  Vladimir V Salmin; Yulia K Komleva; Natalia V Kuvacheva; Andrey V Morgun; Elena D Khilazheva; Olga L Lopatina; Elena A Pozhilenkova; Konstantin A Shapovalov; Yulia A Uspenskaya; Alla B Salmina
Journal:  Front Aging Neurosci       Date:  2017-07-26       Impact factor: 5.750
  7 in total

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