OBJECTIVE: Motor and cognitive functions in patients with partial or generalized onset of seizures were evaluated prior to the administration of antiepileptic medication. MATERIAL AND METHODS: Motor function, attention and memory of 52 consecutive newly diagnosed adult patients with partial or generalized seizures were assessed with neuropsychological tests. RESULTS: Patients with partial onset of seizures did not differ from patients with generalized seizures in tests of motor function or attention, nor in tests of learning and memory. Compared to controls patients with epilepsy performed significantly worse on visual motor tasks, mental flexibility and in delayed visual memory. Within the patient group as a whole lower education, higher age and symptomatic epilepsy with more abnormal CT scan findings tended to associate with worse performance in tests of concentration and mental flexibility and tests of memory. CONCLUSION: These findings indicate that newly diagnosed adult patients with partial or generalized onset of seizures prior to treatment with antiepileptic medication experience some problems in visual motor tasks, mental flexibility and memory even without the numerous risk factors for cognitive deficits in epilepsy. In newly diagnosed patients with epilepsy as a whole symptomatic etiology was associated with somewhat more pronounced cognitive problems.
OBJECTIVE: Motor and cognitive functions in patients with partial or generalized onset of seizures were evaluated prior to the administration of antiepileptic medication. MATERIAL AND METHODS: Motor function, attention and memory of 52 consecutive newly diagnosed adult patients with partial or generalized seizures were assessed with neuropsychological tests. RESULTS:Patients with partial onset of seizures did not differ from patients with generalized seizures in tests of motor function or attention, nor in tests of learning and memory. Compared to controls patients with epilepsy performed significantly worse on visual motor tasks, mental flexibility and in delayed visual memory. Within the patient group as a whole lower education, higher age and symptomatic epilepsy with more abnormal CT scan findings tended to associate with worse performance in tests of concentration and mental flexibility and tests of memory. CONCLUSION: These findings indicate that newly diagnosed adult patients with partial or generalized onset of seizures prior to treatment with antiepileptic medication experience some problems in visual motor tasks, mental flexibility and memory even without the numerous risk factors for cognitive deficits in epilepsy. In newly diagnosed patients with epilepsy as a whole symptomatic etiology was associated with somewhat more pronounced cognitive problems.
Authors: Mira Karrasch; Petri Tiitta; Bruce Hermann; Juho Joutsa; Shlomo Shinnar; Juha Rinne; Anu Anttinen; Matti Sillanpää Journal: J Int Neuropsychol Soc Date: 2017-01-10 Impact factor: 2.892
Authors: Jennifer N Pearson; Shane Rowley; Li-Ping Liang; Andrew M White; Brian J Day; Manisha Patel Journal: Neurobiol Dis Date: 2015-07-13 Impact factor: 5.996
Authors: William C Chen; Eric Y Chen; Rahiwa Z Gebre; Michelle R Johnson; Ningcheng Li; Petr Vitkovskiy; Hal Blumenfeld Journal: Epilepsy Behav Date: 2014-01 Impact factor: 2.937
Authors: Naohide Yamamoto; John W Philbeck; Adam J Woods; Daniel A Gajewski; Joeanna C Arthur; Samuel J Potolicchio; Lucien Levy; Anthony J Caputy Journal: PLoS One Date: 2014-05-06 Impact factor: 3.240
Authors: Eugene O Arinzechi; Olubunmi A Ogunrin; Cosmas M Nwosu; Paul O Nwani; Kelechi O Enwereji; Lasbrey A Asomugha; Uche Dimkpa Journal: J Neurosci Rural Pract Date: 2016 Jul-Sep