| Literature DB >> 10685103 |
I Sánchez1, F Gómez-Garibay, J Taboada, B H Ruiz.
Abstract
In the present study we analysed the possible antiviral effect on dengue viruses of different flavonoids extracted and identified at the Chemistry Institute, UNAM, from the Mexican plants Tephrosia madrensis, Tephrosia viridiflora and Tephrosia crassifolia. The flavonoids glabranine and 7-O-methyl-glabranine presented 70% inhibition on the dengue virus at a concentration of 25 microM, while methyl-hildgardtol A, hildgardtol A and elongatine had no effect on viral growth. Our results show that glabranine and 7-O-methyl-glabranine isolated from Tephrosia s.p. exert a dose-dependent inhibitory effect in vitro on the dengue virus. Copyright 2000 John Wiley & Sons, Ltd.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10685103 DOI： 10.1002/(sici)1099-1573(200003)14:2<89::aid-ptr569>3.0.co;2-c
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878