Cardiovascular responses to intraosseous injections of prilocaine containing vasoconstrictors.

A study of the cardiovascular responses to prilocaine hydrochloride (Citanest) given by intraosseous injection showed that there were no effects related to the absorption of this anesthetic. The presence of epinephrine in concentrations of 1:2000,000 was detected by its rapid absorption and stimulation of the heart rate. The injection of octapressin with prilocaine hydrochloride was usually accompanied by no heart rate or blood pressure changes. However, the heart rate decreased slightly in a few subjects, and this slower heart rate returned to preinjection values within 5 minutes.