Literature DB >> 10683835

SNAP-25 is present on the Golgi apparatus of retinal neurons.

C Morgans1, J H Brandstätter.   

Abstract

SNAP-25 is a neuronal SNARE protein required for synaptic vesicle exocytosis and neurite outgrowth. Here we show that in addition to synaptic staining, SNAP-25 immunoreactivity is also localized to an intracellular, perinuclear compartment of retinal neurons. Double-labeling with an antibody against the 58 kD resident protein of the trans-golgi network indicates that the intracellular SNAP-25 is localized to the Golgi complex. Immuno-electron microscopic localization of SNAP-25 confirmed its presence on the Golgi apparatus of photoreceptors, bipolar cells, amacrine cells and ganglion cells in the retina. These data implicate SNAP-25 in the trafficking of Golgi-derived vesicles in neurons in addition to the synaptic vesicle cycle.

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Year:  2000        PMID： 10683835     DOI： 10.1097/00001756-200001170-00017

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  9 in total

1.  SNAP25 expression in mammalian retinal horizontal cells.

Authors:  Arlene A Hirano; Johann Helmut Brandstätter; Catherine W Morgans; Nicholas C Brecha
Journal:  J Comp Neurol       Date:  2011-04-01       Impact factor: 3.215

2.  A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.

Authors:  Matthew J Van Hook; Norbert Babai; Zack Zurawski; Yun Young Yim; Heidi E Hamm; Wallace B Thoreson
Journal:  J Neurosci       Date:  2017-03-31       Impact factor: 6.167

3.  Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells.

Authors:  Helen Lee; Nicholas C Brecha
Journal:  Eur J Neurosci       Date:  2010-04-06       Impact factor: 3.386

4.  Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis, but not for membrane targeting.

Authors:  P Washbourne; V Cansino; J R Mathews; M Graham; R D Burgoyne; M C Wilson
Journal:  Biochem J       Date:  2001-08-01       Impact factor: 3.857

Review 5.  The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.

Authors:  Aaron J Mercer; Wallace B Thoreson
Journal:  Vis Neurosci       Date:  2011-11       Impact factor: 3.241

6.  SNAP25, but not syntaxin 1A, recycles via an ARF6-regulated pathway in neuroendocrine cells.

Authors:  Yoshikatsu Aikawa; Xiaofeng Xia; Thomas F J Martin
Journal:  Mol Biol Cell       Date:  2005-11-28       Impact factor: 4.138

7.  Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletion.

Authors:  Jenny M Gunnersen; Annabel Kuek; Joanna A Phipps; Vicki E Hammond; Theresa Puthussery; Erica L Fletcher; Seong-Seng Tan
Journal:  PLoS One       Date:  2009-08-07       Impact factor: 3.240

8.  A second SNARE role for exocytic SNAP25 in endosome fusion.

Authors:  Yoshikatsu Aikawa; Kara L Lynch; Kristin L Boswell; Thomas F J Martin
Journal:  Mol Biol Cell       Date:  2006-02-15       Impact factor: 4.138

9.  Gene expression changes during retinal development and rod specification.

Authors:  Fiona C Mansergh; Matthew Carrigan; Karsten Hokamp; G Jane Farrar
Journal:  Mol Vis       Date:  2015-01-20       Impact factor: 2.367
  9 in total

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