| Literature DB >> 10683617 |
E Quirós1, G Piédrola, C Maroto.
Abstract
To assess the prevalence of GBV-C in patients suffering unknown liver disease we have investigated the GBV-C-RNA in serum of 54 patients: 10 with acute and 32 with chronic non-A-E hepatitis (16 active and 16 persistent), 10 with hepatocellular carcinoma, 2 diagnosed with hepatic fulminant failure, and 91 healthy blood donors (control). PCR with primers from NS3 helicase region was performed and the product was identified by a double strand DNA enzyme immunoassay. GBV appears to infect 40 and 31% of acute or chronic non-A-E hepatitis respectively. Also the GBV genome was found in 1 in 10 samples of hepatocarcinoma, in 2 cases of fulminant hepatitis, and in 1 in 91 of the control group. In spite of these results the role of GBV in the etiology of liver diseases has to be analyzed in more comprehensive studies. Copyright 2000 Wiley-Liss, Inc.Entities:
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Year: 2000 PMID： 10683617 PMCID： PMC6807736
Source DB: PubMed Journal: J Clin Lab Anal ISSN： 0887-8013 Impact factor: 2.352