Literature DB >> 10683368

Gene silencing as a threat to the success of gene therapy.

T H Bestor1.   

Abstract

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Year:  2000        PMID： 10683368      PMCID： PMC289175          DOI： 10.1172/JCI9459

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


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  21 in total

1.  Specific interference with gene function by double-stranded RNA in early mouse development.

Authors:  F Wianny; M Zernicka-Goetz
Journal:  Nat Cell Biol       Date:  2000-02       Impact factor: 28.824

2.  A species of small antisense RNA in posttranscriptional gene silencing in plants.

Authors:  A J Hamilton; D C Baulcombe
Journal:  Science       Date:  1999-10-29       Impact factor: 47.728

3.  Targeted mRNA degradation by double-stranded RNA in vitro.

Authors:  T Tuschl; P D Zamore; R Lehmann; D P Bartel; P A Sharp
Journal:  Genes Dev       Date:  1999-12-15       Impact factor: 11.361

Review 4.  Creation of genomic methylation patterns.

Authors:  T H Bestor; B Tycko
Journal:  Nat Genet       Date:  1996-04       Impact factor: 38.330

5.  Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.

Authors:  R Jaenisch; A Schnieke; K Harbers
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

6.  Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.

Authors:  B G Harvey; P L Leopold; N R Hackett; T M Grasso; P M Williams; A L Tucker; R J Kaner; B Ferris; I Gonda; T D Sweeney; R Ramalingam; I Kovesdi; S Shak; R G Crystal
Journal:  J Clin Invest       Date:  1999-11       Impact factor: 14.808

Review 7.  Epigenetic effects in eukaryotic gene expression.

Authors:  T H Bestor; V L Chandler; A P Feinberg
Journal:  Dev Genet       Date:  1994

8.  The methylation-free status of a housekeeping transgene is lost at high copy number.

Authors:  M Mehtali; M LeMeur; R Lathe
Journal:  Gene       Date:  1990-07-16       Impact factor: 3.688

9.  Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes.

Authors:  T D Palmer; G J Rosman; W R Osborne; A D Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

10.  Activation of endogenous retroviral genomes in Mov strains of mice.

Authors:  T Berleth; P Nobis; R Jaenisch; K Harbers
Journal:  J Gen Virol       Date:  1987-11       Impact factor: 3.891
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  58 in total

1.  Position effects are influenced by the orientation of a transgene with respect to flanking chromatin.

Authors:  Y Q Feng; M C Lorincz; S Fiering; J M Greally; E E Bouhassira
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  In vivo assessment of gene delivery to keratinocytes by lentiviral vectors.

Authors:  Ulrich Kuhn; Atsushi Terunuma; Wolfgang Pfutzner; Ruth Ann Foster; Jonathan C Vogel
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

Review 3.  Above and within the genome: epigenetics past and present.

Authors:  F D Urnov; A P Wolffe
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-04       Impact factor: 2.673

Review 4.  Gene delivery into primary T cells: overview and characterization of a transgenic model for efficient adenoviral transduction.

Authors:  Vincent Hurez; Robin D Hautton; James Oliver; R James Matthews; Casey K Weaver
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

5.  Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo.

Authors:  W Pfutzner; A Terunuma; C L Tock; E K Snead; T M Kolodka; M M Gottesman; L Taichman; J C Vogel
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-16       Impact factor: 11.205

Review 6.  Safe harbours for the integration of new DNA in the human genome.

Authors:  Michel Sadelain; Eirini P Papapetrou; Frederic D Bushman
Journal:  Nat Rev Cancer       Date:  2011-12-01       Impact factor: 60.716

Review 7.  Hematopoietic stem cell engineering at a crossroads.

Authors:  Isabelle Rivière; Cynthia E Dunbar; Michel Sadelain
Journal:  Blood       Date:  2011-11-17       Impact factor: 22.113

8.  A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors.

Authors:  Fang Zhang; Amy R Frost; Mike P Blundell; Olivia Bales; Michael N Antoniou; Adrian J Thrasher
Journal:  Mol Ther       Date:  2010-06-29       Impact factor: 11.454

Review 9.  A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19.

Authors:  Harjeet Singh; Helen Huls; Partow Kebriaei; Laurence J N Cooper
Journal:  Immunol Rev       Date:  2014-01       Impact factor: 12.988

10.  Technological advances in precision medicine and drug development.

Authors:  Elaine Maggi; Nicole E Patterson; Cristina Montagna
Journal:  Expert Rev Precis Med Drug Dev       Date:  2016-05-05
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