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Literature DB >> 10683367

Epigenetic gene silencing in cancer.

B Tycko¹.

Abstract

Entities: Disease

Mesh：

Substances：
Histone Deacetylases

Year: 2000 PMID： 10683367 PMCID： PMC289180 DOI： 10.1172/JCI9462

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

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37 in total

1. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.

Authors: E Batlle; E Sancho; C Francí; D Domínguez; M Monfar; J Baulida; A García De Herreros
Journal: Nat Cell Biol Date: 2000-02 Impact factor: 28.824

2. Epigenetic lesions at the H19 locus in Wilms' tumour patients.

Authors: T Moulton; T Crenshaw; Y Hao; J Moosikasuwan; N Lin; F Dembitzer; T Hensle; L Weiss; L McMorrow; T Loew; W Kraus; W Gerald; B Tycko
Journal: Nat Genet Date: 1994-07 Impact factor: 38.330

Review 3. DNA methyltransferases.

Authors: T H Bestor; G L Verdine
Journal: Curr Opin Cell Biol Date: 1994-06 Impact factor: 8.382

4. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

Authors: M Okano; D W Bell; D A Haber; E Li
Journal: Cell Date: 1999-10-29 Impact factor: 41.582

5. Analysis of aberrant methylation of the VHL gene by transgenes, monochromosome transfer, and cell fusion.

Authors: I Kuzmin; L Geil; H Ge; U Bengtsson; F M Duh; E J Stanbridge; M I Lerman
Journal: Oncogene Date: 1999-10-07 Impact factor: 9.867

6. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

Authors: E Li; T H Bestor; R Jaenisch
Journal: Cell Date: 1992-06-12 Impact factor: 41.582

7. Tumour-suppressor activity of H19 RNA.

Authors: Y Hao; T Crenshaw; T Moulton; E Newcomb; B Tycko
Journal: Nature Date: 1993-10-21 Impact factor: 49.962

8. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.

Authors: Y Hoshikawa; H J Kwon; M Yoshida; S Horinouchi; T Beppu
Journal: Exp Cell Res Date: 1994-09 Impact factor: 3.905

9. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Authors: J G Herman; F Latif; Y Weng; M I Lerman; B Zbar; S Liu; D Samid; D S Duan; J R Gnarra; W M Linehan
Journal: Proc Natl Acad Sci U S A Date: 1994-10-11 Impact factor: 11.205

10. Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.

Authors: T Taniguchi; M J Sullivan; O Ogawa; A E Reeve
Journal: Proc Natl Acad Sci U S A Date: 1995-03-14 Impact factor: 11.205

40 in total

Epigenetic gene silencing in cancer.

1. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.

2. Epigenetic lesions at the H19 locus in Wilms' tumour patients.

Review 3. DNA methyltransferases.

4. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

5. Analysis of aberrant methylation of the VHL gene by transgenes, monochromosome transfer, and cell fusion.

6. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

7. Tumour-suppressor activity of H19 RNA.

8. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.

9. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

10. Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.

Review 1. Above and within the genome: epigenetics past and present.

2. Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome.

3. Preliminary study of the relationship between promoter methylation of the ANGPTL2 gene and coronary heart disease.

4. Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers.

5. Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.

6. A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma.

Review 7. Analysis of epigenetic alterations to chromatin during development.

8. Epigenetic change in E-cadherin and COX-2 to predict chronic periodontitis.

9. Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts.

10. Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer.