| Literature DB >> 10683007 |
S C Piscitelli, A H Burstein, D Chaitt, R M Alfaro, J Falloon.
Abstract
St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.Entities:
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Year: 2000 PMID： 10683007 DOI： 10.1016/S0140-6736(99)05712-8
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321