Literature DB >> 10682661

Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer.

M Palicio1, I Blanco, S Tórtola, I González, E Marcuello, J Brunet, F Lluis, J J González-Aguilera, M A Peinado, G Capella.   

Abstract

A polymorphism in hMSH2 gene has been associated with an increased susceptibility to develop colorectal cancer (CRC). Here we show that it is a genetic risk factor for CRC in the Spanish population. However, its presence does not apparently affect hMSH2 function.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10682661      PMCID： PMC2363304          DOI： 10.1054/bjoc.1999.0959

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  10 in total

1.  A truncated hMSH2 transcript occurs as a common variant in the population: implications for genetic diagnosis.

Authors:  L Xia; W Shen; F Ritacca; A Mitri; L Madlensky; T Berk; Z Cohen; S Gallinger; B Bapat
Journal:  Cancer Res       Date:  1996-05-15       Impact factor: 12.701

2.  p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.

Authors:  S Tortola; E Marcuello; I González; G Reyes; R Arribas; G Aiza; F J Sancho; M A Peinado; G Capella
Journal:  J Clin Oncol       Date:  1999-05       Impact factor: 44.544

3.  An intronic germline transition in the HNPCC gene hMSH2 is associated with sporadic colorectal cancer.

Authors:  C Goessl; J Plaschke; S Pistorius; M Hahn; S Frank; M Hampl; H Görgens; R Koch; H D Saeger; H K Schackert
Journal:  Eur J Cancer       Date:  1997-10       Impact factor: 9.162

4.  Clues to the pathogenesis of familial colorectal cancer.

Authors:  L A Aaltonen; P Peltomäki; F S Leach; P Sistonen; L Pylkkänen; J P Mecklin; H Järvinen; S M Powell; J Jen; S R Hamilton
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

5.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

Authors:  R Fishel; M K Lescoe; M R Rao; N G Copeland; N A Jenkins; J Garber; M Kane; R Kolodner
Journal:  Cell       Date:  1993-12-03       Impact factor: 41.582

6.  Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients.

Authors:  B Liu; R Parsons; N Papadopoulos; N C Nicolaides; H T Lynch; P Watson; J R Jass; M Dunlop; A Wyllie; P Peltomäki; A de la Chapelle; S R Hamilton; B Vogelstein; K W Kinzler
Journal:  Nat Med       Date:  1996-02       Impact factor: 53.440

7.  Genetic susceptibility to colorectal cancer in patients under 45 years of age.

Authors:  N R Hall; P J Finan; B Ward; G Turner; D T Bishop
Journal:  Br J Surg       Date:  1994-10       Impact factor: 6.939

8.  Intron splice acceptor site sequence variation in the hereditary non-polyposis colorectal cancer gene hMSH2.

Authors:  N R Hall; G R Taylor; P J Finan; R D Kolodner; W F Bodmer; S E Cottrell; I Frayling; D T Bishop
Journal:  Eur J Cancer       Date:  1994       Impact factor: 9.162

9.  A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis.

Authors:  T A Brentnall; C E Rubin; D A Crispin; A Stevens; R H Batchelor; R C Haggitt; M P Bronner; J P Evans; L E McCahill; N Bilir
Journal:  Gastroenterology       Date:  1995-07       Impact factor: 22.682

10.  Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.

Authors:  Y Ionov; M A Peinado; S Malkhosyan; D Shibata; M Perucho
Journal:  Nature       Date:  1993-06-10       Impact factor: 49.962
  10 in total
  2 in total

1.  Intronic and promoter polymorphisms of hMLH1/hMSH2 and colorectal cancer risk in Heilongjiang Province of China.

Authors:  Guangxiao Li; Fulan Hu; Fengshun Yuan; Jialong Fan; Zhifu Yu; Zhiwei Wu; Xiaojuan Zhao; Ye Li; Shuying Li; Jiesheng Rong; Binbin Cui; Xinshu Dong; Huiping Yuan; Yashuang Zhao
Journal:  J Cancer Res Clin Oncol       Date:  2015-01-06       Impact factor: 4.553

2.  Polymorphisms of mismatch repair gene hMLH1 and hMSH2 and risk of gastric cancer in a Chinese population.

Authors:  Xian-Qiu Xiao; Wei-DA Gong; Shi-Zhi Wang; Zheng-Dong Zhang; Xiao-Ping Rui; Guo-Zhong Wu; Feng Ren
Journal:  Oncol Lett       Date:  2011-12-06       Impact factor: 2.967
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.