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Literature DB >> 10682657

Hypermethylation of ribosomal DNA in human breast carcinoma.

P S Yan¹, F J Rodriguez, D E Laux, M R Perry, S B Standiford, T H Huang.

Abstract

We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression.

Entities: Disease Species

Mesh：

Substances：
DNA, Ribosomal

Year: 2000 PMID： 10682657 PMCID： PMC2363317 DOI： 10.1054/bjoc.1999.0955

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

12 in total

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