Literature DB >> 1068197

Laboratory characteristics of an attenuated influenza type A (H3N2) virus ('Alice' strain).

M Lobmann, A Delem, J Peetermans, C Huygelen.   

Abstract

The Alice strain of live attenuated influenza virus was obtained by selection of a gamma inhibitor-resistant strain from a virus recombinant between A/PR/8/34 (HON1) and A/England/42/72 (H3N2). Its behaviour in vitro and in vivo was studied. Three marker systems were investigated: resistance to serum inhibitors, growth capacity at high temperature and low sensitivity to amantadine hydrochloride. In ferrets the strain was found to be attenuated and immunogenic. Passages in man, animals and eggs have not affected its resistance to gamma inhibitors.

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Year:  1976        PMID： 1068197      PMCID： PMC2129854          DOI： 10.1017/s0022172400024608

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN： 0022-1724


  15 in total

1.  Kaolin treatment of sera for removal of nonspecific inhibitors to Asian strains of influenza virus.

Authors:  L SPENCE
Journal:  Proc Soc Exp Biol Med       Date:  1960-02

2.  Influenza virus plaque formation in different species of cell monolayers.

Authors:  A S Beare; K A Keast
Journal:  J Gen Virol       Date:  1974-03       Impact factor: 3.891

3.  Growth and pathogenicity of influenza viruses in organ cultures of ciliated epithelium. I. Experiments in ferret and human tissue.

Authors:  K Hara; A S Beare; D A Tyrrell
Journal:  Arch Gesamte Virusforsch       Date:  1974

4.  Immunity to influenza in ferrets. I. Response to live and killed virus.

Authors:  C W Potter; J S Oxford; S L Shore; C McLaren; C Stuart-Harris
Journal:  Br J Exp Pathol       Date:  1972-04

5.  Hybrid formation of influenza virus at 25 .

Authors:  H F Maassab; A P Kendal; F M Davenport
Journal:  Proc Soc Exp Biol Med       Date:  1972-03

6.  Laboratory characteristics of influenza A viruses attenuated for man.

Authors:  H Willers; A S Beare
Journal:  Arch Gesamte Virusforsch       Date:  1970

7.  Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man.

Authors:  B R Murphy; E G Chalhub; S R Nusinoff; R M Chanock
Journal:  J Infect Dis       Date:  1972-08       Impact factor: 5.226

8.  Attenuation of human influenza A viruses.

Authors:  A S Beare; M L Bynoe
Journal:  Br Med J       Date:  1969-10-25

9.  Recombinant influenza-A viruses as live vaccines for man. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines.

Authors:  A S Beare; T S Hall
Journal:  Lancet       Date:  1971-12-11       Impact factor: 79.321

10.  Evaluation of influenza virus mutants for possible use in a live virus vaccine.

Authors:  J Mills; J Van Kirk; D A Hill; R M Chanock
Journal:  Bull World Health Organ       Date:  1969       Impact factor: 9.408
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  6 in total

1.  Influenza virus infection of a newborn rats: virulence of recombinant strains prepared from a cold-adapted, attenuated parent.

Authors:  M I Mahmud; H F Maassab; R Jennings; C W Potter
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

2.  Transmissibility of influenza viruses in hamsters.

Authors:  M J Ali; C Z Teh; R Jennings; C W Potter
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

3.  Infant rat model of attenuation for recombinant influenza viruses prepared from cold-adapted attenuated A/Ann Arbor/6/60.

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4.  Protective efficacy of RIT 4025, a live attenuated influenza vaccine strain, and evaluation of heterotypic immunity to influenza A viruses in ferrets.

Authors:  A Delem
Journal:  J Hyg (Lond)       Date:  1977-10

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6.  Serosurveillance for pandemic influenza A (H1N1) 2009 virus infection in domestic elephants, Thailand.

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  6 in total

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