| Literature DB >> 10681448 |
L Masat1, J Caldwell, R Armstrong, H Khoshnevisan, R Jessberger, B Herndier, M Wabl, D Ferrick.
Abstract
SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.Entities:
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Year: 2000 PMID： 10681448 PMCID： PMC15774 DOI： 10.1073/pnas.040374497
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205