Literature DB >> 10680821

Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies.

K Iwasa1, M Takamori, K Komai, Y Mori.   

Abstract

The authors studied sera from 36 patients with Lambert-Eaton myasthenic syndrome (LEMS) by immunoblots using the recombinant protein derived from the DNA sequence encoding for the domain III S5-S6 linker of the P/Q-type voltage-gated calcium channel al subunit. The results of 18 patients were positive for antibodies to this recombinant protein. The results of 2 of 10 patients with lung cancer without LEMS were also positive.

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Year:  2000        PMID： 10680821     DOI： 10.1212/wnl.54.3.757

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  6 in total

Review 1.  Voltage gated calcium channel antibody-related neurological diseases.

Authors:  Can Ebru Bekircan-Kurt; Eda Derle Çiftçi; Aslı Tuncer Kurne; Banu Anlar
Journal:  World J Clin Cases       Date:  2015-03-16       Impact factor: 1.337

2.  Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo.

Authors:  Yaping Joyce Liao; Parsa Safa; Yi-Ren Chen; Raymond A Sobel; Edward S Boyden; Richard W Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-13       Impact factor: 11.205

Review 3.  Ca2+ channels as targets of neurological disease: Lambert-Eaton Syndrome and other Ca2+ channelopathies.

Authors:  Michael T Flink; William D Atchison
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

Review 4.  Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy.

Authors:  Meleeneh Kazarian; Ite A Laird-Offringa
Journal:  Mol Cancer       Date:  2011-03-30       Impact factor: 27.401

Review 5.  The association between Lambert-Eaton myasthenic syndrome and small cell lung carcinoma.

Authors:  Sarah Ew Briggs; Paul Gozzard; Denis C Talbot
Journal:  Immunotargets Ther       Date:  2013-05-21

Review 6.  Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system.

Authors:  Nese Sinmaz; Tina Nguyen; Fiona Tea; Russell C Dale; Fabienne Brilot
Journal:  J Neuroinflammation       Date:  2016-08-30       Impact factor: 8.322
  6 in total

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