OBJECTIVES: The purpose of this study was to examine the frequency of delusions and hallucinations in patients with Alzheimer's disease (AD) and to investigate factors associated with each or the combination of the two. DESIGN: This was a cross-sectional, case-control study. SETTING: Neuropsychiatry and Memory Group, The Johns Hopkins University, USA. PARTICIPANTS: Three hundred and forty-two community-residing patients with probable AD according to NINCDS/ADRDA criteria were included in the study. MEASURES: Patients were assessed clinically for the presence of psychotic symptoms using the DSM-IV glossary definitions. The patients were also rated on standardized measures of cognitive impairment, depression, extrapyramidal symptoms, functional impairment and general health. RESULTS: Seventy-five (22%) AD patients had delusions only, nine (3%) had hallucinations only and 30 (9%) had both delusions and hallucinations. Hallucinations were associated with less education, African-American race, more severe dementia, longer duration of illness, falls and use of anxiolytics. Delusions were associated with older age, depression, aggression, poor general health and use of antihypertensives. Patients with both delusions and hallucinations were similar to the patients with delusions only. CONCLUSIONS: This study confirms the high prevalence of psychotic symptoms in AD patients encountered in clinical practice and suggests that individual psychotic symptoms have different associations. Copyright 2000 John Wiley & Sons, Ltd.
OBJECTIVES: The purpose of this study was to examine the frequency of delusions and hallucinations in patients with Alzheimer's disease (AD) and to investigate factors associated with each or the combination of the two. DESIGN: This was a cross-sectional, case-control study. SETTING: Neuropsychiatry and Memory Group, The Johns Hopkins University, USA. PARTICIPANTS: Three hundred and forty-two community-residing patients with probable AD according to NINCDS/ADRDA criteria were included in the study. MEASURES: Patients were assessed clinically for the presence of psychotic symptoms using the DSM-IV glossary definitions. The patients were also rated on standardized measures of cognitive impairment, depression, extrapyramidal symptoms, functional impairment and general health. RESULTS: Seventy-five (22%) ADpatients had delusions only, nine (3%) had hallucinations only and 30 (9%) had both delusions and hallucinations. Hallucinations were associated with less education, African-American race, more severe dementia, longer duration of illness, falls and use of anxiolytics. Delusions were associated with older age, depression, aggression, poor general health and use of antihypertensives. Patients with both delusions and hallucinations were similar to the patients with delusions only. CONCLUSIONS: This study confirms the high prevalence of psychotic symptoms in ADpatients encountered in clinical practice and suggests that individual psychotic symptoms have different associations. Copyright 2000 John Wiley & Sons, Ltd.
Authors: Sandra Barral; Badri N Vardarajan; Dolly Reyes-Dumeyer; Kelley M Faber; Thomas D Bird; Debby Tsuang; David A Bennett; Roger Rosenberg; Bradley F Boeve; Neill R Graff-Radford; Alison M Goate; Martin Farlow; Rafael Lantigua; Martin Z Medrano; Xinbing Wang; M Ilyas Kamboh; Mahmud Muhiedine Barmada; Daniel J Schaid; Tatiana M Foroud; Elise A Weamer; Ruth Ottman; Robert A Sweet; Richard Mayeux Journal: Neurobiol Aging Date: 2015-08-15 Impact factor: 4.673
Authors: Elise A Weamer; Mary Ann A DeMichele-Sweet; Yona K Cloonan; Oscar L Lopez; Robert A Sweet Journal: J Clin Psychiatry Date: 2016-12 Impact factor: 4.384
Authors: J Ellul; N Archer; C M L Foy; M Poppe; H Boothby; H Nicholas; R G Brown; S Lovestone Journal: J Neurol Neurosurg Psychiatry Date: 2006-09-29 Impact factor: 10.154
Authors: Lirong Wang; Jian Ying; Peihao Fan; Elise A Weamer; Mary Ann A DeMichele-Sweet; Oscar L Lopez; Julia K Kofler; Robert A Sweet Journal: Am J Geriatr Psychiatry Date: 2019-03-27 Impact factor: 4.105
Authors: Katherine A Treiber; Constantine G Lyketsos; Chris Corcoran; Martin Steinberg; Maria Norton; Robert C Green; Peter Rabins; David M Stein; Kathleen A Welsh-Bohmer; John C S Breitner; JoAnn T Tschanz Journal: Int Psychogeriatr Date: 2008-02-21 Impact factor: 3.878
Authors: Martin Steinberg; Kyle Hess; Chris Corcoran; Michelle M Mielke; Maria Norton; John Breitner; Robert Green; Jeannie Leoutsakos; Kathleen Welsh-Bohmer; Constantine Lyketsos; Joann Tschanz Journal: Int J Geriatr Psychiatry Date: 2013-05-17 Impact factor: 3.485