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Literature DB >> 10679461

Structural basis of mRNA cap recognition by proteins.

Abstract

Crystal structures have recently become available for two proteins (VP39 and eIF4E) complexed with their cognate ligand - the mRNA cap. Despite their total structural dissimilarity, both proteins bind N7-methylguanine between two parallel aromatic sidechains. The resulting stacked arrangement governs their high specificity for the alkylated form of the nucleobase.

Entities: Chemical Gene

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Year: 2000 PMID： 10679461 DOI： 10.1016/s0959-440x(99)00053-6

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

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Cited

30 in total

1. Investigation of a conserved stacking interaction in target site recognition by the U1A protein.

Authors: Jerome C Shiels; Jacob B Tuite; Scott J Nolan; Anne M Baranger
Journal: Nucleic Acids Res Date: 2002-01-15 Impact factor: 16.971

2. Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system.

Authors: L Aravind; E V Koonin
Journal: Genome Res Date: 2000-08 Impact factor: 9.043

Structural basis of mRNA cap recognition by proteins.

1. Investigation of a conserved stacking interaction in target site recognition by the U1A protein.

2. Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system.

3. mRNAs biotinylated within the 5' cap and protected against decapping: new tools to capture RNA-protein complexes.

4. Complete cap 4 formation is not required for viability in Trypanosoma brucei.

5. The 2'-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei.

6. eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.

7. Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid.

8. Insights into the molecular determinants involved in cap recognition by the vaccinia virus D10 decapping enzyme.

Review 9. The oncogene eIF4E: using biochemical insights to target cancer.

10. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps.