Literature DB >> 10679457

DNA helicases: 'inching forward'.

P Soultanas1, D B Wigley.   

Abstract

Recently determined crystal structures of PcrA helicase complexed with a DNA substrate have revealed details of the helicase mechanism. PcrA and UvrD helicases have been shown to be functional as monomers, challenging previous suggestions that all helicases are required to be oligomeric. Crystal structures of the hexameric helicases RepA and T7 gene 4 explain the formation of hexameric assemblies from identical monomers with RecA-like folds, but their molecular mechanism remains elusive.

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Year:  2000        PMID： 10679457     DOI： 10.1016/s0959-440x(99)00059-7

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  43 in total

1.  Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.

Authors:  S Datta; M M Prabu; M B Vaze; N Ganesh; N R Chandra; K Muniyappa; M Vijayan
Journal:  Nucleic Acids Res       Date:  2000-12-15       Impact factor: 16.971

2.  Visualization of unwinding activity of duplex RNA by DbpA, a DEAD box helicase, at single-molecule resolution by atomic force microscopy.

Authors:  Arnon Henn; Ohad Medalia; Shu-Ping Shi; Michal Steinberg; Francois Franceschi; Irit Sagi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

3.  Measuring motion on DNA by the type I restriction endonuclease EcoR124I using triplex displacement.

Authors:  K Firman; M D Szczelkun
Journal:  EMBO J       Date:  2000-05-02       Impact factor: 11.598

4.  Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii.

Authors:  R M Story; H Li; J N Abelson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

5.  Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function.

Authors:  G Sianidis; S Karamanou; E Vrontou; K Boulias; K Repanas; N Kyrpides; A S Politou; A Economou
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

6.  Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.

Authors:  P Soultanas; M S Dillingham; P Wiley; M R Webb; D B Wigley
Journal:  EMBO J       Date:  2000-07-17       Impact factor: 11.598

7.  Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase.

Authors:  M S Dillingham; P Soultanas; P Wiley; M R Webb; D B Wigley
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

8.  Rearrangement of structured RNA via branch migration structures catalysed by the highly related DEAD-box proteins p68 and p72.

Authors:  O G Rössler; A Straka; H Stahl
Journal:  Nucleic Acids Res       Date:  2001-05-15       Impact factor: 16.971

9.  Measurement of steady-state kinetic parameters for DNA unwinding by the bacteriophage T4 Dda helicase: use of peptide nucleic acids to trap single-stranded DNA products of helicase reactions.

Authors:  B Nanduri; R L Eoff; A J Tackett; K D Raney
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

10.  Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane.

Authors:  Eran Or; Amiel Navon; Tom Rapoport
Journal:  EMBO J       Date:  2002-09-02       Impact factor: 11.598
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