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Literature DB >> 10679411

Tlr4: central component of the sole mammalian LPS sensor.

Abstract

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

Entities: Chemical Gene Species

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Year: 2000 PMID： 10679411 DOI： 10.1016/s0952-7915(99)00046-1

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

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Cited

211 in total

Review 1. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.

Authors: G Zhang; S Ghosh
Journal: J Clin Invest Date: 2001-01 Impact factor: 14.808

2. Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation.

Authors: D Filipp; K Alizadeh-Khiavi; C Richardson; A Palma; N Paredes; O Takeuchi; S Akira; M Julius
Journal: Proc Natl Acad Sci U S A Date: 2001-01-16 Impact factor: 11.205

Review 3. Present concepts on the inflammatory modulators with special reference to cytokines.

Authors: A S J P A M Van Miert
Journal: Vet Res Commun Date: 2002-02 Impact factor: 2.459

4. Epithelia: not just physical barriers.

Authors: Tomas Ganz
Journal: Proc Natl Acad Sci U S A Date: 2002-03-19 Impact factor: 11.205

5. Peptidoglycan induces mobilization of the surface marker for activation marker CD66b in human neutrophils but not in eosinophils.

Authors: Eva Mattsson; Terese Persson; Pia Andersson; Jan Rollof; Arne Egesten
Journal: Clin Diagn Lab Immunol Date: 2003-05

Tlr4: central component of the sole mammalian LPS sensor.

Review 1. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.

2. Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation.

Review 3. Present concepts on the inflammatory modulators with special reference to cytokines.

4. Epithelia: not just physical barriers.

5. Peptidoglycan induces mobilization of the surface marker for activation marker CD66b in human neutrophils but not in eosinophils.

Review 6. Chaperonin 60 unfolds its secrets of cellular communication.

Review 7. The immunopathogenesis of meningococcal disease.

Review 8. Toll-like receptors in ocular surface disease.

9. Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases.

10. Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets.