Literature DB >> 10679410

Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice.

R S Abraham1, C S David.   

Abstract

The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.

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Year:  2000        PMID： 10679410     DOI： 10.1016/s0952-7915(99)00060-6

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  7 in total

Review 1.  Genetic bases of autoimmune hepatitis.

Authors:  Albert J Czaja; Derek G Doherty; Peter T Donaldson
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199

Review 2.  To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.

Authors:  Marshall Behrens; Michele Smart; David Luckey; Harvinder Luthra; Veena Taneja
Journal:  J Autoimmun       Date:  2011-06-12       Impact factor: 7.094

3.  HLA-DR alleles determine responsiveness to Borrelia burgdorferi antigens in a mouse model of self-perpetuating arthritis.

Authors:  Bettina Panagiota Iliopoulou; Mireia Guerau-de-Arellano; Brigitte T Huber
Journal:  Arthritis Rheum       Date:  2009-12

Review 4.  What can the HLA transgenic mouse tell us about autoimmune diabetes?

Authors:  F S Wong; L Wen
Journal:  Diabetologia       Date:  2004-09-02       Impact factor: 10.122

5.  A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice.

Authors:  Giuseppina Pennesi; Mary J Mattapallil; Shu-Hui Sun; Dody Avichezer; Phyllis B Silver; Zaruhi Karabekian; Chella S David; Paul A Hargrave; J Hugh McDowell; W Clay Smith; Barbara Wiggert; Larry A Donoso; Chi-Chao Chan; Rachel R Caspi
Journal:  J Clin Invest       Date:  2003-04       Impact factor: 14.808

6.  Etiopathogenesis of insulin autoimmunity.

Authors:  Norio Kanatsuna; George K Papadopoulos; Antonis K Moustakas; Ake Lenmark
Journal:  Anat Res Int       Date:  2012-02-22

7.  Identification of antigenic epitopes on human allergens: studies with HLA transgenic mice.

Authors:  Svetlana P Chapoval; Chella S David
Journal:  Environ Health Perspect       Date:  2003-02       Impact factor: 9.031
  7 in total

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