Literature DB >> 10679398

The role of IL-18 in innate immunity.

S Akira1.   

Abstract

IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response.

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Year:  2000        PMID： 10679398     DOI： 10.1016/s0952-7915(99)00051-5

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  87 in total

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