Literature DB >> 10679367

Oxynitrilases for asymmetric C-C bond formation.

D V Johnson1, A A Zabelinskaja-Mackova, H Griengl.   

Abstract

Oxynitrilases for the preparation of (R)- or (S)-cyanohydrins are now readily available. The research efforts of a number of groups have established these enzymes as catalysts with significant potential for application to asymmetric synthesis. Advances made in molecular cloning and genetics have delivered information on the oxynitrilase mechanism of action and sufficient quantities of enzyme to satisfy industrial requirements.

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Year:  2000        PMID: 10679367     DOI: 10.1016/s1367-5931(99)00059-9

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN: 1367-5931            Impact factor:   8.822


  3 in total

1.  Conversion of sterically demanding α,α-disubstituted phenylacetonitriles by the arylacetonitrilase from Pseudomonas fluorescens EBC191.

Authors:  Stefanie Baum; Dael S Williamson; Trevor Sewell; Andreas Stolz
Journal:  Appl Environ Microbiol       Date:  2011-10-21       Impact factor: 4.792

2.  Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran.

Authors:  Z Jane Wang; Hans Renata; Nicole E Peck; Christopher C Farwell; Pedro S Coelho; Frances H Arnold
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-06       Impact factor: 15.336

3.  Activity and enantioselectivity of the hydroxynitrile lyase MeHNL in dry organic solvents.

Authors:  Monica Paravidino; Menno J Sorgedrager; Romano V A Orru; Ulf Hanefeld
Journal:  Chemistry       Date:  2010-07-05       Impact factor: 5.236

  3 in total

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