Literature DB >> 10679362

How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures.

R D Mullins1.   

Abstract

In most cells, the structure of the actin cytoskeleton is regulated by Rho-family G proteins. Recent work has outlined a highly conserved signaling pathway from G protein activation to actin assembly. The key downstream components are WASP family proteins - adaptor molecules that bind multiple signaling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functional protein complex that nucleates and crosslinks actin filaments.

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Year:  2000        PMID： 10679362     DOI： 10.1016/s0955-0674(99)00061-7

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  40 in total

1.  Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP.

Authors:  H Yamaguchi; H Miki; S Suetsugu; L Ma; M W Kirschner; T Takenawa
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

2.  Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments.

Authors:  M J Dayel; E A Holleran; R D Mullins
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

3.  Functional characterization and localization of the Aspergillus nidulans formin SEPA.

Authors:  Kathryn E Sharpless; Steven D Harris
Journal:  Mol Biol Cell       Date:  2002-02       Impact factor: 4.138

4.  Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1.

Authors:  Raymond V Fucini; Ji-Long Chen; Catherine Sharma; Michael M Kessels; Mark Stamnes
Journal:  Mol Biol Cell       Date:  2002-02       Impact factor: 4.138

Review 5.  Alpha-catenin: at the junction of intercellular adhesion and actin dynamics.

Authors:  Agnieszka Kobielak; Elaine Fuchs
Journal:  Nat Rev Mol Cell Biol       Date:  2004-08       Impact factor: 94.444

6.  Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex.

Authors:  Alexander E Kelly; Heather Kranitz; Volker Dötsch; R Dyche Mullins
Journal:  J Biol Chem       Date:  2005-12-23       Impact factor: 5.157

7.  The N-terminus of Dictyostelium Scar interacts with Abi and HSPC300 and is essential for proper regulation and function.

Authors:  Diana Caracino; Cheryl Jones; Mark Compton; Charles L Saxe
Journal:  Mol Biol Cell       Date:  2007-02-21       Impact factor: 4.138

8.  EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability.

Authors:  Janneth Peralta-Ramírez; J Manuel Hernandez; Rebeca Manning-Cela; José Luna-Muñoz; Carlos Garcia-Tovar; Jean-Philippe Nougayréde; Eric Oswald; Fernando Navarro-Garcia
Journal:  Infect Immun       Date:  2008-06-16       Impact factor: 3.441

9.  A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.

Authors:  J R Peterson; R S Lokey; T J Mitchison; M W Kirschner
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-11       Impact factor: 11.205

10.  A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.

Authors:  Daniele Canzio; Maofu Liao; Nariman Naber; Edward Pate; Adam Larson; Shenping Wu; Diana B Marina; Jennifer F Garcia; Hiten D Madhani; Roger Cooke; Peter Schuck; Yifan Cheng; Geeta J Narlikar
Journal:  Nature       Date:  2013-03-13       Impact factor: 49.962
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