| Literature DB >> 10678997 |
D Taramelli1, S Brambilla, G Sala, A Bruccoleri, C Tognazioli, L Riviera-Uzielli, J R Boelaert.
Abstract
Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei.Entities:
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Year: 2000 PMID: 10678997 PMCID: PMC97338 DOI: 10.1128/IAI.68.3.1724-1726.2000
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441