Literature DB >> 10678997

Effects of iron on extracellular and intracellular growth of Penicillium marneffei.

D Taramelli1, S Brambilla, G Sala, A Bruccoleri, C Tognazioli, L Riviera-Uzielli, J R Boelaert.   

Abstract

Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei.

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Year:  2000        PMID: 10678997      PMCID: PMC97338          DOI: 10.1128/IAI.68.3.1724-1726.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  16 in total

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Review 2.  Altered iron metabolism in HIV infection: mechanisms, possible consequences, and proposals for management.

Authors:  J R Boelaert; G A Weinberg; E D Weinberg
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3.  Development of an in vitro macrophage system to assess Penicillium marneffei growth and susceptibility to nitric oxide.

Authors:  M Cogliati; A Roverselli; J R Boelaert; D Taramelli; L Lombardi; M A Viviani
Journal:  Infect Immun       Date:  1997-01       Impact factor: 3.441

4.  Cell-mediated immunity in host resistance against infection caused by Penicillium marneffei.

Authors:  N Kudeken; K Kawakami; N Kusano; A Saito
Journal:  J Med Vet Mycol       Date:  1996 Nov-Dec

5.  Differential effects of iron load on basal and interferon-gamma plus lipopolysaccharide enhance anticryptococcal activity by the murine microglial cell line BV-2.

Authors:  S Saleppico; J R Boelaert; F Omodeo Salè; R Mazzolla; P Morucci; F Bistoni; E Blasi
Journal:  J Neuroimmunol       Date:  1999-01-01       Impact factor: 3.478

6.  Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies.

Authors:  J R Boelaert; M de Locht; J Van Cutsem; V Kerrels; B Cantinieaux; A Verdonck; H W Van Landuyt; Y J Schneider
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

7.  Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis.

Authors:  S L Newman; L Gootee; G Brunner; G S Deepe
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

8.  The heme moiety of malaria pigment (beta-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-alpha production by lipopolysaccharide-stimulated macrophages.

Authors:  D Taramelli; N Basilico; E Pagani; R Grande; D Monti; M Ghione; P Olliaro
Journal:  Exp Parasitol       Date:  1995-12       Impact factor: 2.011

9.  Disseminated Penicillium marneffei infection in southeast Asia.

Authors:  K Supparatpinyo; C Khamwan; V Baosoung; K E Nelson; T Sirisanthana
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10.  Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

Authors:  G Weiss; G Werner-Felmayer; E R Werner; K Grünewald; H Wachter; M W Hentze
Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307

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  8 in total

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2.  Inhibition of intramacrophage growth of Penicillium marneffei by 4-aminoquinolines.

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Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

3.  Serum stimulates growth of and proteinase secretion by Aspergillus fumigatus.

Authors:  Anna H T Gifford; Jodine R Klippenstein; Margo M Moore
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

4.  Novel role for albumin in innate immunity: serum albumin inhibits the growth of Blastomyces dermatitidis yeast form in vitro.

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Journal:  Infect Immun       Date:  2003-11       Impact factor: 3.441

5.  Differential cytokine pattern in the spleens and livers of BALB/c mice infected with Penicillium marneffei: protective role of gamma interferon.

Authors:  Francesca Sisto; Annarita Miluzio; Orazio Leopardi; Maurizio Mirra; Johan R Boelaert; Donatella Taramelli
Journal:  Infect Immun       Date:  2003-01       Impact factor: 3.441

6.  Nodular Sclerosing Hodgkin Lymphoma Combined with Disseminated Talaromyces marneffei Infection: A Case Report.

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Review 7.  Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms.

Authors:  Kritsada Pruksaphon; Joshua D Nosanchuk; Kavi Ratanabanangkoon; Sirida Youngchim
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Review 8.  Adaptation to macrophage killing by Talaromyces marneffei.

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  8 in total

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