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Literature DB >> 10678991

Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae.

M K Zenni¹, P C Giardina, H A Harvey, J Shao, M R Ketterer, D M Lubaroff, R D Williams, M A Apicella.

Abstract

Gonococcal entry into primary human urethral epithelial cells (HUEC) can occur by macropinocytosis. Scanning and transmission electron microscopy revealed lamellipodia surrounding gonococci, and confocal laser scanning microscopy analysis showed organisms colocalized with M(r) 70,000 fluorescein isothiocyanate-labeled dextran within the cells. Phosphoinositide 3-kinase inhibitors and an actin polymerization inhibitor prevented macropinocytic entry of gonococci into HUEC.

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Year: 2000 PMID： 10678991 PMCID： PMC97332 DOI： 10.1128/IAI.68.3.1696-1699.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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