[Prognosis prediction of S-phase fraction and p53, c-erbB-2, estrogen receptor, progesterone receptor in axillary node-negative breast cancer].

The prognostic factors in 180 axillary node-negative breast cancer patients with more than 5 year follow-up were searched for with multiple regression. Based on the regression results, the cases with treatment failure in 5 year and the cases with 5 year disease free survival were matched at 1:2 ratio. Then the c-erbB-2 protein, p53 Protein, estrogen receptor (ER), progesterone receptor (PR) and the S-phase fraction (SPF) were measured in paraffin-embedded breast cancer tissue. The results were analysed with log-rank test and Cox-Model. Among the biobehaviour factors measured, the SPF was the strongest prognosis predictor for ANN. The 5 year disease free survival rate of ANN with SPF < 10% or > 10% was 94% and 52% respectively (P < 0.001). The treatment failure relative risk of patients with SPF > 10% ANN was 11.31. The relative risk of other four factors was respectively, PR 3.58 (P < 0.002), ER 2.93 (P < 0.05), p53 1.44 (P > 0.3), c-erbB-2 1.38 (P > 0.5). The combination of PR or EP with SPF could make the relative risk even higher.