| Literature DB >> 10676919 |
Abstract
In this review, our knowledge concerning the structure and function of the spleen is summarized. The unique architecture of the spleen allows for interactions between the circulatory, reticuloendothelial, and immune systems. Based on these interactions in conjunction with its microanatomy, the spleen is able to maintain the integrity of the blood and respond to circulating antigens. However, this can be a double-edged sword in the case of patients suffering from autoimmune diseases such as immune thrombocytopenic purpura since the spleen can be the site of both antibody production and circulating cell destruction.Entities:
Mesh:
Year: 2000 PMID: 10676919 DOI: 10.1016/s0037-1963(00)90113-6
Source DB: PubMed Journal: Semin Hematol ISSN: 0037-1963 Impact factor: 3.851