| Literature DB >> 10675710 |
R J van Maanen1, I M Tijhof, J M Damen, J W Zwikker, J H Beijnen.
Abstract
The degradation of N,N',N"-triethylenephosphoramide (TEPA) in aqueous solutions has been investigated over a pH range of 3-14. Samples were analyzed using a gas chromatographic system with nitrogen/phosphorus selective detection. The degradation kinetics were studied as function of pH, sodium chloride concentration and temperature. The degradation of TEPA in buffers follows pseudo first order kinetics. The logk(obs)8 the methoxy derivative of TEPA was formed, as a consequence of the applied procedure.Entities:
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Year: 2000 PMID： 10675710 DOI： 10.1016/s0378-5173(99)00444-5
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875