| Literature DB >> 10675704 |
X Yuchun1, L Huizhou, C Jiayong.
Abstract
The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization, under different base and substrate concentrations, is established and experimentally verified.Entities:
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Year: 2000 PMID： 10675704 DOI： 10.1016/s0378-5173(99)00438-x
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875