Literature DB >> 10675281

Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats.

P Arivazhagan1, P Juliet, C Panneerselvam.   

Abstract

The effect of dl-alpha-lipoic acid on lipid peroxidation and antioxidants status has been studied in the blood of young and aged rats. dl-alpha-lipoic acid, an antioxidant, was administered intraperitoneally for 7 and 14 days. Enzymatic and non-enzymatic antioxidant levels decreased with age but this decrease was attenuated by dl-alpha-lipoic acid. Lipid peroxide levels increased with age, and were decreased by lipoic acid administration. These results suggest that biochemical lesions which are considered to be part of the normal ageing process are neutralized by dl-alpha-lipoic acid.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10675281     DOI： 10.1006/phrs.1999.0594

Source DB:  PubMed          Journal:  Pharmacol Res        ISSN： 1043-6618            Impact factor:   7.658


  6 in total

Review 1.  Dietary supplements and cardiovascular disease.

Authors:  R M DeBusk
Journal:  Curr Atheroscler Rep       Date:  2000-11       Impact factor: 5.113

2.  Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin-deficient Mdx mice.

Authors:  Karim Hnia; Gerald Hugon; François Rivier; Ahmed Masmoudi; Jacques Mercier; Dominique Mornet
Journal:  Am J Pathol       Date:  2007-02       Impact factor: 4.307

3.  Age-related protective effect of deprenyl on changes in the levels of diagnostic marker enzymes and antioxidant defense enzymes activities in cerebellar tissue in Wistar rats.

Authors:  Manju V Subramanian; T J James
Journal:  Cell Stress Chaperones       Date:  2010-03-13       Impact factor: 3.667

4.  Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia.

Authors:  S Ghibu; B Lauzier; S Delemasure; S Amoureux; P Sicard; C Vergely; A Muresan; C Mogosan; L Rochette
Journal:  Mol Cell Biochem       Date:  2008-10-07       Impact factor: 3.396

5.  Protective effects of alpha-lipoic Acid on oleic Acid-induced acute lung injury in rats.

Authors:  Funda Gülcü Bulmuş; Mehmet Ferit Gürsu; Mehmet Hamdi Muz; Ihsan Yaman; Ozgür Bulmuş; Fatih Sakin
Journal:  Balkan Med J       Date:  2013-09-01       Impact factor: 2.021

6.  Dietary lipoic acid influences antioxidant capability and oxidative status of broilers.

Authors:  Peng Chen; Qiu-Gang Ma; Cheng Ji; Jian-Yun Zhang; Li-Hong Zhao; Yong Zhang; Yong-Ze Jie
Journal:  Int J Mol Sci       Date:  2011-11-29       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.