Literature DB >> 10674715

Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein.

N J Ede1, S N Eagle, G Wickham, A M Bray, B Warne, K Shoemaker, S Rosenberg.   

Abstract

The solid phase synthesis of a set of peptide aldehydes derived from the NS5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrated using an oxazolidine linker and the Multipin method. Deletion of the P6 and P5 residues results in a dramatic loss of inhibitory activity.

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Year:  2000        PMID： 10674715     DOI： 10.1002/(SICI)1099-1387(200001)6:1<11::AID-PSC229>3.0.CO;2-#

Source DB:  PubMed          Journal:  J Pept Sci        ISSN： 1075-2617            Impact factor:   1.905


  6 in total

1.  Covalent Antiviral Agents.

Authors:  Sako Mirzaie; Fatemeh Abdi; Amin GhavamiNejad; Brian Lu; Xiao Yu Wu
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

2.  Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog.

Authors:  John S Schneekloth; John L Sanders; John Hines; Craig M Crews
Journal:  Bioorg Med Chem Lett       Date:  2006-05-11       Impact factor: 2.823

3.  Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.

Authors:  Anamika Singh; Andrzej Wilczynski; Jerry R Holder; Rachel M Witek; Marvin L Dirain; Zhimin Xiang; Arthur S Edison; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2011-02-09       Impact factor: 7.446

4.  Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.

Authors:  Pavla Fajtová; Saša Štefanić; Martin Hradilek; Jan Dvořák; Jiří Vondrášek; Adéla Jílková; Lenka Ulrychová; James H McKerrow; Conor R Caffrey; Michael Mareš; Martin Horn
Journal:  PLoS Negl Trop Dis       Date:  2015-06-03

5.  Solid-phase synthesis and screening of a library of C-terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease.

Authors:  Nicholas J Ede; Jeffrey Hill; Joma K Joy; Anne-Marie Ede; Merran L Koppens
Journal:  J Pept Sci       Date:  2012-09-18       Impact factor: 1.905

6.  Expanding the Scope of the Cleavable N-(methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates.

Authors:  Aapo Aho; Antti Äärelä; Heidi Korhonen; Pasi Virta
Journal:  Molecules       Date:  2021-01-18       Impact factor: 4.411
  6 in total

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