| Literature DB >> 10673109 |
J W Corbett1, L A Gearhart, S S Ko, J D Rodgers, B C Cordova, R M Klabe, S K Erickson-Viitanen.
Abstract
Benzothiadiazine non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV have been synthesized via a novel process to afford active inhibitors, with the most potent compound exhibiting an IC90 = 180 nM in a whole cell assay. The 2,2-dioxide-1H-2,1,3-benzothiadiazine ring system was constructed in one step from 2-amino-5-chlorobenzonitrile.Entities:
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Year: 2000 PMID： 10673109 DOI： 10.1016/s0960-894x(99)00672-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823